Gene: [07p1/IGFB1] insulin-like growth factor binding protein 1 (25-35kD); placental protein 12 (IGF-binding protein); [IGFBP1 IBP1 ]


GEN

The gene length is 5.9 kb. Exons: 4.

MOP

Insulin-like growth factors (IGF; see GEM:12q23/IGF1) are circulating in serum, being tightly bound with specific IGF-binding proteins, which are present in human as two major forms, low-molecular one (25-35 kD) and high-molecular one (150 kD)."

FAG

The following IGFB genes are identified in the human genome: GEM:07p1/IGFB1; GEM:02q3/IGFB2; GEM:07p1/IGFB3; GEM:17q/IGFB4; GEM:00.0/IGFB5; GEM:12^/IGFB6; GEM:04q12/IGFB7; GEM:01p/IGFB10. See also GEM:06^/IGFALS."

REF

LOC,FAG,EVO,POL "Alitalo &: CCG, 51, (HGM10), 950, 1989a
LOC,FAG,EVO,POL "Alitalo &: Hum Genet, 83, 335-338, 1989b
REV,NOM "Ballard &: J Clin Endocrinol Metab, 70, 817-818, 1990
CLO,SEQ,EXP,LOC,CYG "Brinkman A &: EMBO J, 7, N8, 2417-2423, 1988
LOC,FAG "Ehrenborg E &: Genomics, 12, 497-502, 1992
LOC "Ekstrand J &: Genomics, 6, 413-418, 1990
FUN,MEB "Forbes &: BBRC, 157, N1, 196-202, 1989
CLO,PRO "Julkunen M &: FEBS Lett, 236, 295-302, 1988

SWI

SWISSPROT: P08833

KEY

sex, trp, horm

CLA

coding, basic

LOC

07 p13-12

MIM

MIM: 146730

SYN

IGFBP1 IBP1

鸯铗痂蝈 蜞赕:

  • IGFBP1 (裂刃1, IGF-砚琨忄栝 徨腩 蜩镟 1)