Gene: [09q32/ORM1] orosomucoid 1 (alpha-1-acid glycoprotein 1); [AGP1 ]
COM | [1] The MIM
catalogue indicates the regional location as q34.1-34.3, with reference to
Allderdice-1986, however, the conclusions of this report are disputed
(Zuffardi-1989, Webb-1988). [2] The HGM catalogue indicates for ORM1 location a more extended region, q31-t. With account for the data on the localization of the gene for the second orosomucoid isoform, which is closely linked to ORM1, the GEM catalogue localizes both genes to q34." |
GEN | The UPS vicinity contains five Alu-repeats; the 5'-UTL region is homologous to those of alpha-1 antitrypsin and haptoglobin genes. An approximate gene structure is like the following: EX1, INT=450 bp; EX2, INT=216 bp; EX3, INT=700 bp; EX4, INT=175 bp; EX5, INT=1090 bp; EX6." |
ASS | The serum level of the protein is increased in acute inflammation, i.e. the protein may be assigned to the class of acute-phase reactants." |
MAP | Loci: GEM:09q32/ORM2;
GEM:09q341/AK1; GEM:09q34/ABO. [1] ORM1/ORM2-[17cM]-AK1-[13cM]-ABO. [1a] ORM-[27cM]-ABO. [1b] ORM1-[3.3kb]-ORM2." |
REF | LOC,LIN,CYG,COM
"Allderdice PW &: AJHG, 39, 612-617, 1986 PRO,COD,SEQ,EXP "Board PG &: Gene, 44, 127-131, 1986 GEN,SEQ "Dente L &: EMBO J, 6, 2289-2296, 1987 PRO,COD,SEQ,EXP "Dente L &: NAR, 13, N11, 3941-3952, 1985 PRO,COD,SEQ,EXP "Merritt CM, Board PG: Gene, 66, 97-106, 1988 LOC,CYG,PRO,FAG "Rocchi M &: Hum Genet, 74, 30-33, 1986 LOC,LIN,CYG,COM "Webb GC &: CCG, 47, 18-21, 1988 LOC,LIN,CYG,COM "Zuffardi O &: Hum Genet, 82, 17-19, 1989 |
SWI | SWISSPROT: P02763 |
KEY | hem, serp |
CLA | coding, basic |
LOC | 09 q32 |
MIM | MIM: 138600 |
SYN | AGP1 |
