Gene: [09q341/ABL1] Abelson murine leukemia viral oncogene homolog 1; protein tyrosine phosphokinase (oncogene ABL1); chronic myelogenous leukemia (CML; Ph'-oncomarker);


PAT

Ph+ chronic myelogenous leukemia is associated with the reciprocal t(9;22) translocation culminating in the production of the chimeric p210(bcr/abl) protein possessing elevated protein tyrosine kinase activity relative to the normal c-abl tyrosine kinase."

FAG

On the relationship of ABL1 with chronic myelogenous leukemia and Ph'-oncomarker (Philadelphia oncomarker resulted from the translocation <9q34;22q11>), see GEM:22q1122/BCR1."

REF

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LOC "Groffen J &: J Cell Physiol, 3, (Suppl), 179-191, 1984
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LOC,CYG,MOL,PAT "Westbrook CA &: PNAS, 82, 8742-8746, 1985

SWI

SWISSPROT: P00519

KEY

onc, hem, ont

CLA

coding, basic

LOC

09 q34.1

MIM

MIM: 189980

EZN

ENZYME: 2.7.1.112

鸯铗痂蝈 蜞赕:

  • Gene: [17p131/TP53] tumor protein p53; colorectal cancer-related sequence in chromosome 17p; Li-Fraumeni syndrome (LFS; MIM:151623); [LFS ]
  • Gene: [09q341/SURF1] surfeit 1 (mouse housekeeping gene homolog); Leigh syndrome (MIM:256000);
  • 缅 c-Abl
  • Gene: [12p13/ETV6] ets translocation variant gene 6 (TEL oncogene); [TEL ]
  • Gene: [00.0/DOK1] docking protein 1 (downstream of tyrosine kinase 1); [p62dok ]
  • Gene: [04p163/SH3BP2] SH3 domain binding protein 2;
  • Gene: [01q2/ABL2] Abelson murine leukemia viral oncogene homolog 2 (arg); protein tyrosine kinase ABL2;
  • ABL1 缅