Gene: [09q341/ABL1] Abelson murine leukemia viral oncogene homolog 1; protein tyrosine phosphokinase (oncogene ABL1); chronic myelogenous leukemia (CML; Ph'-oncomarker);
PAT | Ph+ chronic myelogenous leukemia is associated with the reciprocal t(9;22) translocation culminating in the production of the chimeric p210(bcr/abl) protein possessing elevated protein tyrosine kinase activity relative to the normal c-abl tyrosine kinase." |
FAG | On the relationship of ABL1 with chronic myelogenous leukemia and Ph'-oncomarker (Philadelphia oncomarker resulted from the translocation <9q34;22q11>), see GEM:22q1122/BCR1." |
REF | PAT,EXP,REL "Bartram
CR &: CCG, 37, 415, 1984 HIS,PAT "Bartram CR &: Nature, 306, 277-280, 1983 GEN,MAF "Bernards A &: Mol Cell Biol, 7, 3231-3236, 1987 PAT,EXP,REL "Chan LC &: Nature, 325, 635-637, 1987 PAT,EXP,REL "Clark SS &: Science, 235, 85-88, 1987 PAT,EXP,REL "Croce CM &: Cancer Res, 46, 6019-6023, 1986 PAT,EXP,REL "de Klein A &: NAR, 14, 7071-7082, 1986 PAT,EXP,REL "de Klein A &: Nature, 300, 765-767, 1982 PAT,EXP,REL "Erikson J &: PNAS, 83, 1807-1811, 1986 LOC "Groffen J &: J Cell Physiol, 3, (Suppl), 179-191, 1984 PAT,EXP,REL "Hanish J &: Genomics, 10, 681-685, 1991 PAT,EXP,REL "Harris RM &: CCG, 58, 1940, 1991 PAT,EXP,REL "Heisterkamp N &: NAR, 16, 10069-10081, 1988 HIS,PAT "Heisterkamp N &: Nature, 306, 239-242, 1983 SEQ,EVO "Hoffmann &: Cell, 35, 393-401, 1983 LOC,FAG "Jhanwar SC &: CCG, 38, 73-75, 1984 PAT,EXP,REL "Kruh GD &: PNAS, 87, 5802-5806, 1990 REV,PAT,MAF "Kurzrock R &: New Engl J Med, 319, N15, 990-998, 1988 PAT,EXP,REL "Kurzrock R &: Nature, 325, 631-635, 1987 PAT,EXP,REL "Maserati E &: Hum Genet, 78, 248-250, 1988 PAT,EXP,REL "Melo JV &: Nature Genet, 8, 318-319, 1994 PAT,EXP,REL "Mes-Masson AM &: PNAS, 83, 9768-9772, 1986 PAT,EXP,REL "Morris CM &: Cancer Genet Cytogenet, 35, 179-197, 1988 PAT,EXP,REL "Morris CM &: Nature, 320, 281-283, 1986 HIS,PAT "Nowell, Hungerford: Science, 132, 1497-?, 1960 PAT,EXP,REL "Poloni ES &: Ann Hum Genet, 59, 43-61, 1995 PAT,EXP,REL "Povey S &: Ann Hum Genet, 58, 177-250, 1994 HIS,PAT "Rowley: Annu Rev Genet, 14, 17-39, 1980 HIS,PAT "Rowley: Nature, 243, 290-293, 1973 PAT,EXP,REL "Stam K &: Mol Cell Biol, 7, 1955-1960, 1987 PAT,EXP,REL "Szabo P &: Mol Biol Med, 5, 139-144, 1988 PAT,EXP,REL "Szcylik C &: Science, 253, 562-565, 1991 LOC,CYG,MOL,PAT "Westbrook CA &: PNAS, 82, 8742-8746, 1985 |
SWI | SWISSPROT: P00519 |
KEY | onc, hem, ont |
CLA | coding, basic |
LOC | 09 q34.1 |
MIM | MIM: 189980 |
EZN | ENZYME: 2.7.1.112 |
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