Gene: [11q1/MDU1] antigen MDU1, heavy subunit (p40, monoclonal antibodies 4F2, 44D7); sodium-calcium exchanger (NACAE); [M4F2 MGP4F2 ]
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COM |
MDU: |
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MOP |
The antigen determinant that is recognized by 4F2 antibodies is located on the surface of the 65-kD subunit of the membrane glycoprotein having MM over 100 kD. The second subunit of this glycoprotein is not glycosylated; it has the MM about 40 kD (Hemler-1982). Nothing is known about its genetics." |
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GEN |
The gene length is about 8 kb. Exons: 9 (Gottesdiener-1988). The peptide product consists of 155 amino acid residues (Lumadue-1987)." |
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REL |
GEM:11p13/CD44:SYN<'MDU2 MDU3' |
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REF |
LOC "Francke U &: Somat Cell Genet, 9, 333-344, 1983 CLO,GEN,EVO "Gottesdiener KM &: Mol Cell Biol, 8, 3809-3819, 1988 FUN,MEB "Haynes BF &: J Immunol, 126, 1409-1414, 1981 FUN,MEB "Hemler ME, Strominger JL: J Immunol, 129, 623-628, 1982 EXP,FUN,MEB "Lindsten T &: Mol Cell Biol, 8, 3820-3826, 1988 CLO,SEQ,PEP,EXP "Lumadue JA &: PNAS, 84, N24, 9204-9208, 1987 FUN,MEB "Michalak M &: JBC, 261, 92-95, 1986 LOC "Peters PG &: Somat Cell Genet, 8, N6, 825-834, 1982 FUN,MEB "Posillico JT &: Clin Res, 33, 385A, 1985 CLO,SEQ,MOP "Quackenbush E &: PNAS, 84, N18, 6526-6530, 1987 EAG,MOU,HUM "Rochelle JM &: Genomics, 14, 26-31, 1992 LOC "Tunnacliffe A &: Somat Cell Genet, 9, N5, 629-642, 1983 |
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KEY |
onc, neu, horm, mem, ion |
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CLA |
coding, basic |
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LOC |
11 q12-13.1 |
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MIM |
MIM: 158070 |
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SYN |
M4F2 MGP4F2 |
