Gene: [11p13/CD44] antigen CD44 (gp90; lymphocyte homing/adhesion receptor; lethal antigen 3); antigen MDU2 (MDU3; monoclonal antibodies A1G3, A3D8); antigen MIC4 (monoclonal antibodies F10.44.2, mab4); Lutheran blood group inhibitor? (MIM:111150; INLU; antigen CD44); [MFI1 S3 MIC4 ]


COM

Antigens MIC4 and MDU3 are described in the MIM Catalogue under the numbers 143040 and 158060?. They were determined to be identical to the product of gene CD44."

FUN

The CD44 peptide possibly inhibits the expression of the Lutheran blood group antigen on the surface of red blood cells."

EXP

Hematopoietic and epithelial forms of antigene CD44 are produced by alternative splicing."

REF

FUN,LOC,CYG,LIN "Ala-Kapee &: CCG, 51, (HGM10), 948-949, 1989
LOC,CYG "Forsberg UH &: Eur J Immunol, 19, 409-412, 1989a
LOC,CYG "Forsberg UH &: Immunogenetics, 29, 405-407, 1989b
LOC,CYG "Francke U &: Somat Cell Genet, 9, 333-334, 1983
LOC,LIN,MOL,MAP "Glaser &: CCG, 46, (HGM9), 620-621, 1987
LOC,CYG "Goodfellow &: Eur J Immunol, 8, 659-663, 1982
MOU,CLO,COD "Lasky &: Cell, 56, 1045-1055, 1989
PEP,MEB "Omary &: Immunogenetics, 27, 460-464, 1988
IDN,FUN,MEB "Stefanova &: Immunogenetics, 29, 402-404, 1989
LOC,CYG "Van Heyningen &: CCG, 40, (HGM8), 768, 1985

KEY

mem, hem, imm

CLA

coding, basic

LOC

11 p13

MIM

MIM: 107269

SYN

MFI1 S3 MIC4

鸯铗痂蝈 蜞赕:

  • Gene: [11q1/MDU1] antigen MDU1, heavy subunit (p40, monoclonal antibodies 4F2, 44D7); sodium-calcium exchanger (NACAE); [M4F2 MGP4F2 ]
  • Gene: [17p133/C1QBP] complement component 1, q subcomponent binding protein; hyaluronan-binding protein 1; splicing factor, arginine/serine-rich 1 associated protein (p32); [HABP1 GC1Q-R ]
  • Gene: [19q132/LU] Lutheran blood group; B-cell adhesion molecule (BCAM); Auberger B antigen; antigen MSK19 (gp95; monoclonal antibody F8); [BCAM MSK19 ]
  • Gene: [02q3/GPC1] glypican 1;
  • Gene: [04q2/SPP1] secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); [OPN BNSP ]