Gene: [11q22/CASP1] caspase 1, apoptosis-related cysteine protease; interleukin 1, beta, convertase;


COM

Alternatively spliced gene, with key role in apoptosis, C elegans ced-3 homolog.

FAG

Members of the ICE/CED-3 protease family play key biologic roles in inflammation and mammalian apoptosis."

NOM

Alnemri-1996 proposed a nomenclature for the human members of this protease family. They recommended use of the trivial name 'caspase' as a root for serial names for all family members. The selection of caspase was based on 2 catalytic properties of these enzymes. The 'c' was intended to reflect a cysteine protease mechanism, and 'aspase' referred to their ability to cleave after aspartic acid, the most distinctive catalytic feature of this protease family. To designate individual family members, caspase was to be followed by an arabic number, assigned on the date of publication. Assignments for the 10 previously described proteases were given. The root symbol for the corresponding gene was to be CASP, and this gene was symbolized CASP1."

MOD

Li-1997 generated ICE-deficient mice through gene targeting technology. ICE-deficient mice developed normally, appeared healthy, and were fertile. Peritoneal macrophages from ICE-deficient mice underwent apoptosis normally upon ATP treatment. Thymocytes from young ICE-deficient mice also underwent apoptosis when triggered by dexamethasone, gamma irradiation, or aging. The most striking result from the study was that the ICE-deficient mice were highly resistant to the lethal effects of endotoxin. With high-dose lipopolysaccharide that killed all wildtype mice within 30 hours, all ICE-deficient mice survived the first 48 hours and 70% of them survived after 7 days. These studies suggested the therapeutic potential of ICE inhibitors in inflammatory diseases such as septic shock and inflammatory bowel diseases."

REL

GEM:07q35/CASP2; GEM:04q34/CASP3; GEM:11q22/CASP4; GEM:11q22/CASP5; GEM:04q2/CASP6; GEM:10q25/CASP7; GEM:00.0/CASP8; GEM:00.0/CASP9; GEM:02q3/CASP10. See also GEM:02q13/IL1A and FAM:IL/00.0."

REF

NOM "Alnemri ES &: Cell, 87, 171-171, 1996
COD,LOC,REL "Alnemri ES &: JBC, 270, 4312-4317, 1995
FUN "Casano FJ &: Genomics, 20, 474-481, 1994
GEN,SEQ "Cerretti DP &: Genomics, 20, 468-473, 1994
COD,SEQ "Cerretti DP &: Science, 256, 97-100, 1992
MOD,MOU "Li P &: J Cell Biochem, 64, 27-32, 1997
LOC "Nasir J &: Mammal Genome, 8, N8, 611-613, 1997
COD,LOC,REL "Smith MW &: Genomics, 17, 699-725, 1993
COD,LOC,REL "Tunnacliffe A &: Genomics, 17, 744-747, 1993
COD,LOC,REL "Vanagaite L &: Genomics, 22, 231-233, 1994

SWI

SWISSPROT: P29466

KEY

imm, pep

CLA

coding, basic

LOC

11 q22.2-.3

MIM

MIM: 147678

EZN

ENZYME: 3.4.22.36