Gene: [12q1/SHMT2] serine hydroxymethyltransferase 2 (mitochondrial);
FUN | [1]
Systematic name: 5,10-methylenetetrahydrofolate:glycine
hydroxymethyltransferase. [2] The catalyzed reaction: 5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine. Cofactor: pyridoxal-phosphate. The enzyme also catalyses the reaction of glycine with acetaldehyde, to form L-threonine." |
REF | CLO,SEQ,LOC "Garrow TA &: JBC, 268, 11910-11916, 1993 LOC "Kao &: PNAS, 64, 1284-1291, 1969 LOC "Law ML &: CCG, 25, 179-180, 1979a LOC "Law ML, Kao: CCG, 24, 102-114, 1979b |
SWI | SWISSPROT: P34897 |
KEY | aac, mito |
CLA | coding, basic |
LOC | 12 q12-14 |
MIM | MIM: 138450 |
EZN | ENZYME: 2.1.2.1 |
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