Gene: [17p112/SHMT1] serine hydroxymethyltransferase 1 (soluble);
FUN | Systematic name: 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase. The catalyzed reaction: 5,10-methylenetetrahydrofolate + glycine + H(2)O = = tetrahydrofolate + L-serine. Cofactor: pyridoxal-phosphate. The enzyme also catalyses the reaction of glycine with acetaldehyde, to form L-threonine." |
REL | GEM:12q1/SHMT2. |
PSG | GEM:01p3/SHMT1P. |
REF | CLO,SEQ,STR,LOC
"Garrow TA &: JBC, 268, 11910-11916, 1993 |
SWI | SWISSPROT: P34896 |
KEY | aac |
CLA | coding, basic |
LOC | 17 p11.2 |
MIM | MIM: 182144 |
EZN | ENZYME: 2.1.2.1 |
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