Gene: [15q2/PEPN] aminopeptidase N (antigen CD13; p150; alanyl aminopeptidase); glycoprotein p150 (CD13; leukocyte; aminopeptidase N);


COM

[1] According to A-B-C-D-E-S aminopeptidase nomenclature, the enzyme PEPN corresponds to aminopeptidase E (Kruse-1988). On the other hand, the gene for aminopeptidase E is mapped in the human genome in Chr 17 (GEM:17q2/PEPE; Wilson-1984).
[2] The old code for aminopeptidase N is EC:3.4.1.1."

MOP

The rpoduct of PEPN was originally identified as a glycoprotein with MM 150 kD, recognized with antibodies MY7 and MCS2. Afterwards, its aminopeptidase activity was found and confirmed (Look-1989). The enzyme is assigned to the family of zinc-containing proteinases."

FUN

Aminopeptidase N splits out almost every N-terminal amino acid though it is especially active with respect to Ala."

TIS

Aminopeptidase N is located on the epithelial cell membranes of kidney and intestine microvilli, as well as on cytoplasmic membranes of some other cells."

FAG

Several peptidase genes have been mapped in the human genome, see GEM:18q23/PEPA."

REF

LOC,NOM,POL "Kruse TA &: CCG, 58, (HGM11), 1993-1994, 1991
LOC,NOM,POL "Kruse TA &: CCG, 51, (HGM10), 1026, 1989
LOC,NOM,POL "Kruse TA &: FEBS Lett, 239, 305-308, 1988
PEP,SEQ,FUN "Look AT &: J Clin Invest, 83, 1299-1307, 1989
PRO,EXP,LOC "Look AT &: J Clin Invest, 78, 914-921, 1986
LOC,POL "Watt VM, Wilard: Hum Genet, 85, 651-654, 1990
COM "Wilson &: Ann Hum Genet, 48, 43-48, 1984

SWI

SWISSPROT: P15144

KEY

imm, pep, mem

CLA

coding, basic

LOC

15 q25-26

MIM

MIM: 151530

EZN

ENZYME: 3.4.11.2

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