Gene: [15q2/PEPN] aminopeptidase N (antigen CD13; p150; alanyl aminopeptidase); glycoprotein p150 (CD13; leukocyte; aminopeptidase N);
COM | [1]
According to A-B-C-D-E-S aminopeptidase nomenclature, the enzyme PEPN
corresponds to aminopeptidase E (Kruse-1988). On the other hand, the gene
for aminopeptidase E is mapped in the human genome in Chr 17 (GEM:17q2/PEPE; Wilson-1984). [2] The old code for aminopeptidase N is EC:3.4.1.1." |
MOP | The rpoduct of PEPN was originally identified as a glycoprotein with MM 150 kD, recognized with antibodies MY7 and MCS2. Afterwards, its aminopeptidase activity was found and confirmed (Look-1989). The enzyme is assigned to the family of zinc-containing proteinases." |
FUN | Aminopeptidase N splits out almost every N-terminal amino acid though it is especially active with respect to Ala." |
TIS | Aminopeptidase N is located on the epithelial cell membranes of kidney and intestine microvilli, as well as on cytoplasmic membranes of some other cells." |
FAG | Several peptidase genes have been mapped in the human genome, see GEM:18q23/PEPA." |
REF | LOC,NOM,POL
"Kruse TA &: CCG, 58, (HGM11), 1993-1994, 1991 LOC,NOM,POL "Kruse TA &: CCG, 51, (HGM10), 1026, 1989 LOC,NOM,POL "Kruse TA &: FEBS Lett, 239, 305-308, 1988 PEP,SEQ,FUN "Look AT &: J Clin Invest, 83, 1299-1307, 1989 PRO,EXP,LOC "Look AT &: J Clin Invest, 78, 914-921, 1986 LOC,POL "Watt VM, Wilard: Hum Genet, 85, 651-654, 1990 COM "Wilson &: Ann Hum Genet, 48, 43-48, 1984 |
SWI | SWISSPROT: P15144 |
KEY | imm, pep, mem |
CLA | coding, basic |
LOC | 15 q25-26 |
MIM | MIM: 151530 |
EZN | ENZYME: 3.4.11.2 |
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