Gene: [17q1/THRA] thyroid hormone receptor, alpha; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1; [ERBA1 THRA2 ]
FAG | [1] The
gene for beta thyroid hormone receptor has been mapped to Chr 3p243 (GEM:03p243/THRB). [2] On oncogene homolog ERBB1 see GEM:07p12/EGFR1. [3] On oncogene homolog ERBB2 see GEM:17q1/EGFR2." |
EXP | Alpha-1 (SWI:P21205) and alpha-2 (SWI:P10827) receptors are produced by alternative splicing." |
MAP | Loci: GEM:17q112/NF1; GEM:17q1/EGFR2; FAM:HOXB/17q2; GEM:17q2/NGFR. [1] See GEM:17q112/NF1." |
HIS | The uncertainty of data on number and localization of THR genes was began with the report of Gosden-1986, where probe ERBA2 (now THRB) was shown to hybridize in situ with two sites on chr 17 - q21.3 and q25, while all consequent studies mapped THRB(ERBA2) to chr 3p. However, Weinberger-1986 demonstrated the existence of about five or six THR genes, of which three (those for beta receptor) being located in chr 3 and the remaining (those for alpha receptor; they are characterized by a longer mRNA, about 5kb) being located in chr 17. In general, this agrees with the original data (Jansson-1983) on the existence of two classes of ERBA(THR) sequences in the human genome, one of the classes having more than one copy." |
REF | EXP,MOL,MEB "Bahn &:
BBRC, 150, N1, 259-262, 1988 PRO,EXP,FAG "Benbrook D, Pfahl: Science, 238, 788-791, 1987 LOC,CYG,MUT "Dayton AI &: PNAS, 81, 4495-4499, 1984 PRO,EXP,FAG "Jansson M &: EMBO J, 2, N4, 561-565, 1983 LOC,PRO "Jhanwar SC &: Somat Cell Mol Genet, 11, N1, 99-102, 1985 SEQ "Laudet V &: NAR, 19, 1105-1112, 1991 LOC,PRO "Mittelman F &: Cancer Genet Cytogenet, 22, 95-98, 1986 SEQ "Miyajima N &: Cell, 57, 31-39, 1989 SEQ "Nakai A &: Mol Endocrinol, 2, 1087-1092, 1988a SEQ "Nakai A &: PNAS, 85, 2781-2785, 1988b EXP,MOL,MEB "Sakurai A &: Mol Endocrinol, 3, 392-399, 1989 MOP "Sap J &: Nature, 324, 635-640, 1986 LOC,PRO "Sheer &: Ann Hum Genet, 49, 167-171, 1985 LOC,CYG,FAG "Spurr NK &: EMBO J, 3, N1, 159-163, 1984 EAG,FAG "Thompson CC &: Science, 237, 1610-1614, 1987 LOC,PRO "van Tuinen P &: Genomics, 1, 374-381, 1987 REV,FAG,EVO "Weinberger C &: Cold Spring Harbor Symp, 51, (Part 2), 759-772, 1986a SEQ "Weinberger C &: Nature, 324, 641-646, 1986b MAG,MAF "Xu WM &: CCG, 51, (HGM10), 1111-1112, 1989 MAG,MAF "Xu WM &: PNAS, 85, N22, 8563-8567, 1988 |
SWI | SWISSPROT: P21205; THA2 P10827 |
KEY | onc, recp, horm |
CLA | coding, basic |
LOC | 17 q11.2-12 |
MIM | MIM: 190120 |
SYN | ERBA1 THRA2 |
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