Gene: [18q211/DCC] suppression of colorectal cancer; colorectal cancer-related sequence in chromosome 18q; tumor suppressor DCC (deleted in colorectal carcinoma); [CRCR1 CRC18 ]
FUN | The tumor supressing effect of this gene (or its product) is not yet confirmed. A chr 17 gene (GEM:17p131/TP53) is supposed to have similar effect in colorectal cancer." |
HIS | MIM-88 registered this gene with reference to Vogelstein-1988. HGM9.5 (1988) registered it, with denotation CRCR1. Later, the gene was excluded from HGM10 (1989) and restored in HGM10.5 (1990), with the denotation DCC (deleted in colorectal carcinoma; Fearon-1990)." |
REF | PRO,GEN,LOC,EXP,MOP,MEB "Fearon ER &: Science, 247, 49-56,
1990 MUT,LOC,CYG,PAT,FAG "Kern &: JAMA, 261, 3099-3103, 1989 MUT,LOC,CYG,PAT,FAG "Law DJ &: Science, 241, 961-965, 1988 MUT,LOC,CYG,PAT,FAG "Vogelstein B &: Science, 244, (14 Apr), 207-211, 1989 |
SWI | SWISSPROT: P43146 |
KEY | onc, git |
CLA | coding, basic |
LOC | 18 q21.1 |
MIM | MIM: 120470 |
SYN | CRCR1 CRC18 |
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