Gene: [18q2133/BCL2] transforming protein BCL-2; B-cell chronic lymphatic leukemia 2 (B-CLL: lymphoma 2);
FUN | Blocks apoptosis. Adenilate cyclase modulator? (Haldar-1989). |
HIS | BCL3 gene (located in 18q21) was previously considered to be a part of gene BCL2. However as early as in HGM10, this name was assigned to the gene in the long arm of chr 19, which was previously referred to as BCL4 (see GEM:19q132/BCL3)." |
FAG | According to Haldar-1989, the product of this gene belong to the group of so called G proteins or adenylate cyclase modulators (see FAM:GNBP/00.0)." |
REL | GEM:15^/BCL2A1; GEM:00.0/BCL2L1; GEM:14q1/BCL2L2. |
REF | GEN,MUT "Aisenberg &:
Blood, 71, N4, 969-972, 1988 GEN,MUT "Amakawa &: Blood, 73, N3, 787-791, 1989 GEN,MUT "Bakhshi A &: PNAS, 84, N8, 2396-2400, 1987 SEQ,EXP "Cleary &: Cell, 47, 19-28, 1987 LOC "Cleary &: J Exp Med, 164, 315-320, 1986 SEQ,EXP "Cleary &: PNAS, 82, N21, 7439-7443, 1985 GEN,MUT "Cotter &: Blood, 73, N5, 1387-1388, 1989 IDN,FUN "Haldar S &: Nature, 342, N6246, 195-198, 1989 MUT "Komaki &: Hum Genet, 103, 435, 1998 EXP,PAT,TIS "Mariano &: Blood, 80, N3, 768-777, 1992 GEN,MUT "Ngan &: Blood, 73, N7, 1759-1762, 1989 EXP,PAT "Ngan &: New Engl J Med, 318, N25, 1638-1644, 1988 GEN,MUT "Tsujimoto Y &: PNAS, 84, N5, 1329-1331, 1987 SEQ,PEP "Tsujimoto Y, Groce: PNAS, 83, N14, 5214-5218, 1986 PRO,LOC "Tsujimoto Y &: Nature, 315, 340-343, 1985a PRO,LOC "Tsujimoto Y &: Science, 228, 1440-1443, 1985b PRO,LOC "Tsujimoto Y &: Science, 229, 1390-1393, 1985c PRO,LOC "Tsujimoto Y &: Science, 226, 1097-1099, 1984 |
SWI | SWISSPROT: P10415 |
KEY | onc, imm, hem |
CLA | coding, basic |
LOC | 18 q21.33 |
MIM | MIM: 151430 |
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