Gene: [19q132/BCL3] B-cell chronic lymphatic leukemia 3 (B-CLL: lymphoma 3); [BCL4 D19S37 ]


COM

Previously BCL3 locus was mapped (McKeithan-1987) with the aid of somatic hybrid cells and gDNA probe p-alpha.5B (a 0.5 kb fragment cloned at BamHI site), which is specific for a DNA sequence tightly linked to BCL3. Afterwards, this sequence was found to be located 16 kb closer to the centromere than the site of hybridization with BCL3-specific probe p-alpha-1.4B (Korneluk-1989a)."

PRO

Probe name: Vector Site Insert (kb) Reference
[1] p-alpha-1.4P: bluescribe PstI 1.4 Korneluk-1989"

POL

Enzyme Alleles in kb/(Popul Freq) (Reference; Probe number)
[1] EcoRI+MluI A1= 9.0/(0.60); A2= 8.0/(0.40) (Harley-1989; Probe [1]):
[2] BanI B1= 3.0/(0.82); B2= 2.2/(0.18) (Harley-1989; MacKenzie-1989; Korneluk-1989; Probe 1; const bands abs)
[3] KpnI C1= 15.0/(?); C2= 4.0/(?) (Korneluk-1989; Probe [1])"

MAP

Loci: GEM:19q134/PRKCG; GEM:19q132/CYP2A6; GEM:19q132/ATP1A3; GEM:19q132/APOC1; GEM:19q132/APOC2; GEM:19q133/CKM; GEM:19q133/DMPK.
[1] See GEM:19q134/PRKCG.
[2] c-D19S8-D19S16-BCL3-APOC2-CKM-DMPK-D19S50-D19S22-qt (MacKenzie-1989)."

REF

COM,FAG "Gauwerky CE &: PNAS, 86, N22, 8867-8871, 1989
LOC,POL,MAP "Harley &: CCG, 51, (HGM10), 1011, 1989
PRO,LOC,MOL,POL,LIN,MAP "Korneluk RG &: Genomics, 4, N2, 146-151, 1989a
POL,MOL "Korneluk RG &: NAR, 17, N14, 5874, 1989b
POL,MOL "Korneluk RG &: NAR, 17, N14, 5875, 1989c
LOC,POL,MAP "MacKenzie TW &: CCG, 51, (HGM10), 1036-1037, 1989
PRO,LOC,LIN "McKeithan TW &: PNAS, 84, N24, 9257-9260, 1987
LOC,LIN,MAP "Roses &: CCG, 51, (HGM10), 1069, 1989
LOC,POL,MAP "Shaw DJ &: Hum Genet, 83, N1, 71-74, 1989
LOC,CYG "Ueshima Y &: Int J Cancer, 36, 287-290, 1985

KEY

onc, imm, hem

CLA

coding, basic

LOC

19 q13.2

MIM

MIM: 109560

SYN

BCL4 D19S37

鸯铗痂蝈 蜞赕:

  • Gene: [18q2133/BCL2] transforming protein BCL-2; B-cell chronic lymphatic leukemia 2 (B-CLL: lymphoma 2);
  • Gene: [11q133/BCL1] B-cell chronic lymphatic leukemia 1 (B-CLL: lymphoma 1);
  • Gene: [19q13/OFC3] orofacial cleft 3;