Gene: [19q132/CYP2A6] cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6; coumarin 7-hydroxilase (microsomal; cytochrome P450-IIA3; MIM:122720);


FAG

CYPABF gene cluster is located in chromosomal segment (FAM:CYP2ABF/19q132). On the CYP2 gene subfamily, see FAM:CYP2/00.0. The summary list of genes of CYP superfamily is presented in FAM:CYP/00.0. The basic bibliography is also given there."

PRO

Gene-specific DNA probe pHP450(1) is a 1.250 kb fragment cloned at PstI site in the plasmid pKT218 (Phillips-1985; Shephard-1985)."

POL

Enzyme Alleles in kb/(Popul Freq) Const Bands in kb (Reference; Probe number)
[1] SstI A1= 9.3/(0.55); CBs= 10.6+6.6+4.4+ (Davis-1987; A2= 5.2; 4.1/(0.45) +3.1+2.5+0.8 Wainwright-1985; Probe 1) SstI A1= 8.5/(?); A2= 4.0/(?) CBs= 9.4+6.0+2.5 (Hulsebos-1986; Probe 1)"

MAP

Loci: GEM:19q132/ATP1A3; GEM:19q134/PRKCG; GEM:19q132/APOC1; GEM:19q132/APOC2; GEM:19q133/CKM; GEM:19q133/DMPK; GEM:19q132/BCL3.
[1] See GEM:19q134/PRKCG."

REL

EVO,FUN: FAM:CYP/00.0

REF

LOC,LIN "Davis MB: Ann Hum Genet, 51, 9-12, 1987
LOC,CYG,MOL,PRO "Davis MB &: Ann Hum Genet, 50, 237-240, 1986
LOC,LIN "Farral &: CCG, 46, (HGM9), 612-613, 1987
LIN,POL "Hulsebos T &: CCG, 43, 47-56, 1986
SEQ,LOC "Miles JS &: NAR, 17, 2907-2917, 1989
LIN,MAP "Mitchell &: CCG, 51, (HGM10), 1045, 1989
LOC,CYG,MOL,PRO "Phillips IR &: Ann Hum Genet, 49, 267-274, 1985a
CLO,SEQ,EXP "Phillips IR &: PNAS, 82, 983-987, 1985b
LIN,MAP "Schonk D &: CCG, 51, (HGM10), 1075, 1989a
LIN,MAP "Schonk D &: Genomics, 4, N3, 384-396, 1989b
LOC,CYG,MOL,PRO "Shephard &: CCG, 40, (HGM8), 741-742, 1985
POL,MOL,LOC "Wainwright BJ &: NAR, 13, 4610, 1985
CLO,SEQ,FAG,EXP,FUN "Yamano S &: Biochemistry, 29, N25, 1322-1329, 1990
CLO,SEQ,EXP "Yamano S &: NAR, 17, 4888, 1989

KEY

xen

CLA

coding, basic

LOC

19 q13.2

MIM

MIM: 123960

EZN

ENZYME: 1.14.14.1

鸯铗痂蝈 蜞赕:

  • Gene: [19q131/RYR1] ryanodine receptor 1 (skeletal muscle; calcium release channel); Ca++ release channel of sarcoplasmic reticulum; malignant hyperthermia susceptibility 1 (King syndrome; MHS1; MIM:145600); central core disease of muscle (
  • Gene: [CYP2ABF/19q132] cytochrome P450, subfamily II in Chr 19q13.2; (CYP2A6 CYP2A7 CYP2A7P1 CYP2A7P2 CYP2A13 CYP2B6 CYP2B7 CYP2B8 CYP2F1)
  • HUGEN-鲨蝾躔铎 P450