Gene: [19q132/CYP2A6] cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6; coumarin 7-hydroxilase (microsomal; cytochrome P450-IIA3; MIM:122720);
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FAG |
CYPABF gene cluster is located in chromosomal segment (FAM:CYP2ABF/19q132). On the CYP2 gene subfamily, see FAM:CYP2/00.0. The summary list of genes of CYP superfamily is presented in FAM:CYP/00.0. The basic bibliography is also given there." |
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PRO |
Gene-specific DNA probe pHP450(1) is a 1.250 kb fragment cloned at PstI site in the plasmid pKT218 (Phillips-1985; Shephard-1985)." |
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POL |
Enzyme Alleles in kb/(Popul Freq) Const Bands in kb
(Reference; Probe number)
[1] SstI A1= 9.3/(0.55); CBs= 10.6+6.6+4.4+ (Davis-1987; A2= 5.2; 4.1/(0.45) +3.1+2.5+0.8 Wainwright-1985; Probe 1) SstI A1= 8.5/(?); A2= 4.0/(?) CBs= 9.4+6.0+2.5 (Hulsebos-1986; Probe 1)" |
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MAP |
Loci: GEM:19q132/ATP1A3; GEM:19q134/PRKCG; GEM:19q132/APOC1;
GEM:19q132/APOC2; GEM:19q133/CKM; GEM:19q133/DMPK; GEM:19q132/BCL3.
[1] See GEM:19q134/PRKCG." |
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REL |
EVO,FUN: FAM:CYP/00.0 |
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REF |
LOC,LIN "Davis MB: Ann Hum Genet, 51, 9-12, 1987 LOC,CYG,MOL,PRO "Davis MB &: Ann Hum Genet, 50, 237-240, 1986 LOC,LIN "Farral &: CCG, 46, (HGM9), 612-613, 1987 LIN,POL "Hulsebos T &: CCG, 43, 47-56, 1986 SEQ,LOC "Miles JS &: NAR, 17, 2907-2917, 1989 LIN,MAP "Mitchell &: CCG, 51, (HGM10), 1045, 1989 LOC,CYG,MOL,PRO "Phillips IR &: Ann Hum Genet, 49, 267-274, 1985a CLO,SEQ,EXP "Phillips IR &: PNAS, 82, 983-987, 1985b LIN,MAP "Schonk D &: CCG, 51, (HGM10), 1075, 1989a LIN,MAP "Schonk D &: Genomics, 4, N3, 384-396, 1989b LOC,CYG,MOL,PRO "Shephard &: CCG, 40, (HGM8), 741-742, 1985 POL,MOL,LOC "Wainwright BJ &: NAR, 13, 4610, 1985 CLO,SEQ,FAG,EXP,FUN "Yamano S &: Biochemistry, 29, N25, 1322-1329, 1990 CLO,SEQ,EXP "Yamano S &: NAR, 17, 4888, 1989 |
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KEY |
xen |
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CLA |
coding, basic |
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LOC |
19 q13.2 |
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MIM |
MIM: 123960 |
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EZN |
ENZYME: 1.14.14.1 |
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