Gene: [19q1/CCNE] cyclin E (G1/S-specific);


FUN

Timing of the mRNA levels suggests that cyclin E plays a role in either the G1/S phase transition or in S phase. So cyclin E might activate the kinase at the beginning of S phase. It can interact with the cdc28 protein to perform its function."

MOP

Cyclin E do not contain 'mitotic destruction motif'. However this protein contain PEST sequences, which have been suggested to target proteins for rapid (and constitutive) degradation (Rogers-1986), near the carboxyl terminus (PEST-FIND score +1)."

EXP

Cyclin E mRNA accumulation was dramatically periodic through the cell cycle, peaking in late G1 near the G1/S phase transition."

EVO

Cyclin E share 58% similarity to human cyclin A vs. 49% similarity to yeast Cln 3 in the most conserved region (including most of the cyclin box)."

REF

LOC "Demetrick DJ &: CCG, 69, 190-192, 1995
MOP,EVO,EAG "see GEM:05q1/CCNB1

KEY

nucm, onc, repr

CLA

coding, basic

LOC

19 q12-13

MIM

MIM: 123837

鸯铗痂蝈 蜞赕:

  • Gene family: cyclins; (CCNA CCNB1 CCNB2 CCNC CCND1 CCND2 CCND2P CCND3 CCND3P CCNE CCNF CCNG1 CCNG2 CCNH CCNL1 CCNT1 CCNT2)
  • HUGEN-鲨觌桧
  • 缅 鲨觌桧 E