Gene: [20^/PTGIS] prostaglandin I2 (prostacyclin) synthase; cytochrome P450, subfamily VIII (prostacyclin synthase);


COM

Although prostacyclin synthase has absorbance spectral features characteristic of the cytochrome P450s, this enzyme has no monooxygenase activity and does not require an external source of electrons to initiate its enzyme reaction (Wang-1996). PGIS has been named CYP8 in the cytochrome P450 superfamily. The gene is also symbolized PGIS for prostaglandin I2 synthase."

FUN

The prostacyclin synthase (PGIS) catalyzes the isomerization of prostaglandin H2 to prostacyclin (prostaglandin I2) which is a potent vasodilator and inhibitor of platelet aggregation."

GEN

The gene length: 60 kb (app.); exons: 10 (Wang-1996).

MOP

PTGIS encodes a polypeptide of 500 amino acids with sequence homology to cholesterol 7-alpha-monooxygenase (GEM:08q1/CYP7A1), a member of the superfamily of cytochrome P450s (FAM:CYP/00.0)."

REF

COD,SEQ "Miyata A &: BBRC, 200, 1728-1734, 1994a
COD,SEQ "Miyata A &: Cell Mol Biol Res, 200, 1728-1734, 1994b
GEN,LOC "Wang L-H, Chen L: BBRC, 226, 631-637, 1996

SWI

SWISSPROT: Q16647

KEY

xen

CLA

coding, basic

LOC

20

MIM

MIM: 601699

EZN

ENZYME: 5.3.99.4

鸯铗痂蝈 蜞赕:

  • 闲窝依秩仕韧 讶鸵狼 (EC 5.3.99.4)
  • PTGIS 沐