Gene: [22q11/MN1] meningioma-associated protein MN1; meningioma chromosome region; [MGCR1 MGCR ]
|
COM |
[1] Using a balanced translocation t(4;22), Lekanne Deprez-1995
isolated a gene they designated MN1 which was disrupted by the
translocation.
[2] GDB points two loci for this gene: MGCR (GDB:G00-120-180) with location in Chr 22 q12.3-t (G00-120-180) and MGCR1-PEN (GDB:G00-580-528) with location in Chr 22 q11 (G00-580-528)." |
|
GEN |
Gene length: 70 kb (app.). Exons: 2 (app. 4.7 kb and 2.8 kb). The cDNA encodes a protein of 1,319 amino acids (Lekanne Deprez-1995)." |
|
ASS |
In sporadic meningiomas, it was found specific loss of expression of a beta-adaptin gene (GEM:22q12/ADTB1)." |
|
MUT |
The MN1 gene is fused to the ETV6 gene (GEM:12p13/ETV6) in the t(12;22), which is observed in some patients with acute myeloid leukemia (Buijs-1995)." |
|
HIS |
[1] In one meningioma case, the loss of homozygosity was found, however,
it was observed in chr 3 (3q24-qt) rather than chr 22 (Farber-1991).
[2] MN1 gene is fused to the TEL gene (600618) in the t(12;22), which is observed in some patients with acute myeloid leukemia (Buijs-1995)." |
|
REF |
LOC,CYG "Arinami T &: J Med Genet, 23, 179-179, 1986 LOC,ABR,PAT "Buijs A &: Oncogene, 10, 1511-1519, 1995 LOC,CYG "Cogen &: CCG, 46, (HGM9), 595, 1987 LOC,CYG "Dumanski JP &: Cancer Res, 50, 5863-5867, 1990 LOC,CYG "Dumanski JP &: PNAS, 84, N24, 9275-9279, 1987 HIS,CAG "Farber U &: CCG, 57, N2-3, 157-158, 1991 PAT,FOG,CYG "Lekanne Deprez RH &: J Neuropath Exp Neurol, 54, 224-235, 1995a CLO,COD,SEQ,LOC "Lekanne Deprez RH &: Oncogene, 10, 1521-1528, 1995b ABR,LIN "Lekanne Deprez RH &: AJHG, 48, 783-790, 1991 LOC,CYG "Meese E &: Hum Genet, 77, 349-351, 1987 LOC,CYG "Seizinger BR &: PNAS, 84, N15, 5419-5423, 1987 LOC,CYG "Zang KD &: Cancer Genet Cytogenet, 6, 249-274, 1982 |
|
KEY |
neu, onc |
|
CLA |
coding, basic |
|
LOC |
22 q11 |
|
MIM |
MIM: 156100 |
|
SYN |
MGCR1 MGCR |
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