Gene: [22q12/ADTB1] adaptin, beta 1 (beta prime); meningioma-associated locus BAM22; [BAM22 AP105A ]
|
GEN |
The gene length: 100 kb (app.); exons: 22 (Peyrard-1996). |
|
FUN |
Adaptins are essential in dynamic processes of intracellular sorting, internalilization, and transport of membrane-spanning receptors via 'clathrin-coated-vesicles'." |
|
MOP |
AP1 coat assembly protein complex of clathrin-coated vesicles is a heterotetramer composed of 2 large components (beta-prime and gamma subunits: GEM:00.0/CLAPG1), a medium 47-kD component (GEM:08p11/CLAPM2), and a small 19-kD component (GEM:00.0/CLAPS1)." |
|
CAG |
Peyrard-1994 suggested that beta 1 adaptin is a meningioma candidate gene (GEM:22q11/MN1) and important to the neurofibromatosis type 2 (see GEM:22q122/NF2)." |
|
REF |
GEN,SEQ,EXP "Peyrard M &: Genomics, 36, 112-117, 1996 CLO,EXP,MUT "Peyrard M &: Hum Mol Genet, 3, 1393-1399, 1994 CLO,SEQ,GEN,LOC "Zucman-Rossi J &: Genomics, 38, N3, 247-254, 1996 |
|
KEY |
neu, onc, mem |
|
CLA |
coding, basic |
|
LOC |
22 q12 |
|
MIM |
MIM: 600157 |
|
SYN |
BAM22 AP105A |
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