Gene superfamily: phosphodiesterases, cyclic nucleotide; (PDE1A PDE1B PDE1C PDE2A PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D PDE6A PDE6B PDE6C PDE6G PDE6H PDE7A PDE8A PDE9A)

SUM

The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDEs have been divided into families based on substrate specificity, affinity, sensitivity to cofactors, and sensitivity to inhibitory drugs: (1) Ca(2+)/calmodulin-dependent; (2) cGMP-stimulated; (3) cGMP-inhibited (GEM:00.0/PDE3A; GEM:11p15/PDE3B); (4) cAMP-specific; (5) cGMP-specific; (6) photoreceptor; (7) high-affinity, cAMP-specific."