Рис. GLA seq.
Нуклеотидная и аминокислотная последовательности
гена альфа-галактозидазы А
(galactosidase alpha; GLA) человека.
ATG CAG CTG AGG AAC CCA GAA CTA CAT CTG GGC TGC GCG CTT GCG
met gln leu arg asn pro glu leu his leu gly cys ala leu ala 15
CTT CGC TTC CTG GCC CTC GTT TCC TGG GAC ATC CCT GGG GCT AGA
leu arg phe leu ala leu val ser trp asp ile pro gly ala arg 30
GCA CTG GAC AAT GGA TTG GCA AGG ACG CCT ACC ATG GGC TGG CTG
ala leu asp asn gly leu ala arg thr pro thr met gly trp leu 45
CAC TGG GAG CGC TTC ATG TGC AAC CTT GAC TGC CAG GAA GAG CCA
his trp glu arg phe met cys asn leu asp cys gln glu glu pro 60
GAT TCC TGC ATC AGT GAG AAG CTC TTC ATG GAG ATG GCA GAG CTC
asp ser cys ile ser glu lys leu phe met glu met ala glu leu 75
ATG GTC TCA GAA GGC TGG AAG GAT GCA GGT TAT GAG TAC CTC TGC
met val ser glu gly trp lys asp ala gly tyr glu tyr leu cys 90
ATT GAT GAC TGT TGG ATG GCT CCC CAA AGA GAT TCA GAA GGC AGA
ile asp asp cys trp met ala pro gln arg asp ser glu gly arg 105
CTT CAG GCA GAC CCT CAG CGC TTT CCT CAT GGG ATT CGC CAG CTA
leu gln ala asp pro gln arg phe pro his gly ile arg gln leu 120
GCT AAT TAT GTT CAC AGC AAA GGA CTG AAG CTA GGG ATT TAT GCA
ala asn tyr val his ser lys gly leu lys leu gly ile tyr ala 135
GAT GTT GGA AAT AAA ACC TGC GCA GGC TTC CCT GGG AGT TTT GGA
asp val gly asn lys thr cys ala gly phe pro gly ser phe gly 150
TAC TAC GAC ATT GAT GCC CAG ACC TTT GCT GAC TGG GGA GTA GAT
tyr tyr asp ile asp ala gln thr phe ala asp trp gly val asp 165
CTG CTA AAA TTT GAT GGT TGT TAC TGT GAC AGT TTG GAA AAT TTG
leu leu lys phe asp gly cys tyr cys asp ser leu glu asn leu 180
GCA GAT GGT TAT AAG CAC ATG TCC TTG GCC CTG AAT AGG ACT GGC
ala asp gly tyr lys his met ser leu ala leu asn arg thr gly 195
AGA AGC ATT GTG TAC TCC TGT GAG TGG CCT CTT TAT ATG TGG CCC
arg ser ile val tyr ser cys glu trp pro leu tyr met trp pro 210
TTT CAA AAG CCC AAT TAT ACA GAA ATC CGA CAG TAC TGC AAT CAC
phe gln lys pro asn tyr thr glu ile arg gln tyr cys asn his 225
TGG CGA AAT TTT GCT GAC ATT GAT GAT TCC TGG AAA AGT ATA AAG
trp arg asn phe ala asp ile asp asp ser trp lys ser ile lys 240
AGT ATC TTG GAC TGG ACA TCT TTT AAC CAG GAG AGA ATT GTT GAT
ser ile leu asp trp thr ser phe asn gln glu arg ile val asp 255
GTT GCT GGA CCA GGG GGT TGG AAT GAC CCA GAT ATG TTA GTG ATT
val ala gly pro gly gly trp asn asp pro asp met leu val ile 270
GGC AAC TTT GGC CTC AGC TGG AAT CAG CAA GTA ACT CAG ATG GCC
gly asn phe gly leu ser trp asn gln gln val thr gln met ala 285
CTC TGG GCT ATC ATG GCT GCT CCT TTA TTC ATG TCT AAT GAC CTC
leu trp ala ile met ala ala pro leu phe met ser asn asp leu 300
CGA CAC ATC AGC CCT CAA GCC AAA GCT CTC CTT CAG GAT AAG GAC
arg his ile ser pro gln ala lys ala leu leu gln asp lys asp 315
GTA ATT GCC ATC AAT CAG GAC CCC TTG GGC AAG CAA GGG TAC CAG
val ile ala ile asn gln asp pro leu gly lys gln gly tyr gln 330
CTT AGA CAG GGA GAC AAC TTT GAA GTG TGG GAA CGA CCT CTC TCA
leu arg gln gly asp asn phe glu val trp glu arg pro leu ser 345
GGC TTA GCC TGG GCT GTA GCT ATG ATA AAC CGG CAG GAG ATT GGT
gly leu ala trp ala val ala met ile asn arg gln glu ile gly 360
GGA CCT CGC TCT TAT ACC ATC GCA GTT GCT TCC CTG GGT AAA GGA
gly pro arg ser tyr thr ile ala val ala ser leu gly lys gly 375
GTG GCC TGT AAT CCT GCC TGC TTC ATC ACA CAG CTC CTC CCT GTG
val ala cys asn pro ala cys phe ile thr gln leu leu pro val 390
AAA AGG AAG CTA GGG TTC TAT GAA TGG ACT TCA AGG TTA AGA AGT
lys arg lys leu gly phe tyr glu trp thr ser arg leu arg ser 405
CAC ATA AAT CCC ACA GGC ACT GTT TTG CTT CAG CTA GAA AAT ACA
his ile asn pro thr gly thr val leu leu gln leu glu asn thr 420
ATG CAG ATG TCA TTA AAA GAC TTA CTT TAA
met gln met ser leu lys asp leu leu ter
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