Рис. SMPD1 seq.
Нуклеотидная и аминокислотная последовательности
гена сфингомиелиназы человека
(sphingomyelin phosphodiesterase 1; SMPD 1).
ATG CCC CGC TAC GGA GCG TCA CTC CGC CAG AGC TGC CCC AGG TCC
met pro arg tyr gly ala ser leu arg gln ser cys pro arg ser 15
GGC CGG GAG CAG GGA CAA GAC GGG ACC GCC GGA GCC CCC GGA CTC
gly arg glu gln gly gln asp gly thr ala gly ala pro gly leu 30
CTT TGG ATG GGC CTG GCG CTG GCG CTG GCG CTG GCG CTG GCG CTG
leu trp met gly leu ala leu ala leu ala leu ala leu ala leu 45
GCT CTG TCT GAC TCT CGG GTT CTC TGG GCT CCG GCA GAG GCT CAC
ala leu ser asp ser arg val leu trp ala pro ala glu ala his 60
CCT CTT TCT CCC CAA GGC CAT CCT GCC AGG TTA CAT CGC ATA GTG
pro leu ser pro gln gly his pro ala arg leu his arg ile val 75
CCC CGG CTC CGA GAT GTC TTT GGG TGG GGG AAC CTC ACC TGC CCA
pro arg leu arg asp val phe gly trp gly asn leu thr cys pro 90
ATC TGC AAA GGT CTA TTC ACC GCC ATC AAC CTC GGG CTG AAG AAG
ile cys lys gly leu phe thr ala ile asn leu gly leu lys lys 105
GAA CCC AAT GTG GCT CGC GTG GGC TCC GTG GCC ATC AAG CTG TGC
glu pro asn val ala arg val gly ser val ala ile lys leu cys 120
AAT CTG CTG AAG ATA GCA CCA CCT GCC GTG TGC CAA TCC ATT GTC
asn leu leu lys ile ala pro pro ala val cys asn ser ile val 135
CAC CTC TTT GAG GAT GAC ATG GTG GAG GTG TGG AGA CGC TCA GTG
his leu phe glu asp asp met val glu val trp arg arg ser val 150
CTG AGC CCA TCT GAG GCC TGT GGC CTG CTC CTG GGC TCC ACC TGT
leu ser pro ser glu ala cys gly leu leu leu gly ser thr cys 165
GGG CAC TGG GAC ATT TTC TCA TCT TGG AAC ATC TCT TTG CCT ACT
gly his trp asp ile phe ser ser trp asn ile ser leu pro thr 180
GTG CCG AAG CCG CCC CCC AAA CCC CCT AGC CCC CCA GCC CCA GGT
val pro lys pro pro pro lys pro pro ser pro pro ala pro gly 195
GCC CCT GTC AGC CGC ATC CTC TTC CTC ACT GAC CTG CAC TGG GAT
ala pro val ser arg ile leu phe leu thr asp leu his trp asp 210
CAT GAC TAC CTG GAG GGC ACG GAC CCT GAC TGT GCA GAC CCA CTG
his asp tyr leu glu gly thr asp pro asp cys ala asp pro leu 225
TGC TGC CGC CGG GGT TCT GGC CTG CCG CCC GCA TCC CGG CCA GGT
cys cys arg arg gly ser gly leu pro pro ala ser arg pro gly 240
GCC GGA TAC TGG GGC GAA TAC AGC AAG TGT GAC CTG CCC CTG AGG
ala gly tyr trp gly glu tyr ser lys cys asp leu pro leu arg 255
ACC CTG GAG AGC CTG TTG AGT GGG CTG GGC CCA GCC GGC CCT TTT
thr leu glu ser leu leu ser gly leu gly pro ala gly pro phe 270
GAT ATG GTG TAC TGG ACA GGA GAC ATC CCC GCA CAT GAT GTC TGG
asp met val tyr trp thr gly asp ile pro ala his asp val trp 285
CAC CAG ACT CGT CAG GAC CAA CTG CGG GCC CTG ACC ACC GTC ACA
his gln thr arg gln asp gln leu arg ala leu thr thr val thr 300
GCA CTT GTG AGG AAG TTC CTG GGG CCA GTG CCA GTG TAC CCT GCT
ala leu val arg lys phe leu gly pro val pro val tyr pro ala 315
GTG GGT AAC CAT GAA AGC ACA CCT GTC AAT AGC TTC CCT CCC CCC
val gly asn his glu ser thr pro val asn ser phe pro pro pro 330
TTC ATT GAG GGC AAC CAC TCC TCC CGC TGG CTC TAT GAA GCG ATG
phe ile glu gly asn his ser ser arg trp leu tyr glu ala met 345
GCC AAG GCT TGG GAG CCC TGG CTG CCT GCC GAA GCC CTG CGC ACC
ala lys ala trp glu pro trp leu pro ala glu ala leu arg thr 360
CTC AGA ATT GGG GGG TTC TAT GCT CTT TCC CCA TAC CCC GGT CTC
leu arg ile gly gly phe tyr ala leu ser pro tyr pro gly leu 375
CGC CTC ATC TCT CTC AAT ATG AAT TTT TGT TCC CGT GAG AAC TTC
arg leu ile ser leu asn met asn phe cys ser arg glu asn phe 390
TGG CTC TTG ATC AAC TCC ACG GAT CCC GCA GGA CAG CTC CAG TGG
trp leu leu ile asn ser thr asp pro ala gly gln leu gln trp 405
CTG GTG GGG GAG CTT CAG GCT GCT GAG GAT CGA GGA GAC AAA GTG
leu val gly glu leu gln ala ala glu asp arg gly asp lys val 420
CAT ATA ATT GGC CAC ATT CCC CCA GGG CAC TGT CTG AAG AGC TGG
his ile ile gly his ile pro pro gly his cys leu lys ser trp 435
AGC TGG AAT TAT TAC CGA ATT GTA GCC AGG TAT GAG AAC ACC CTG
ser trp asn tyr tyr arg ile val ala arg tyr glu asn thr leu 450
GCT GCT CAG TTC TTT GGC CAC ACT CAT GTG GAT GAA TTT GAG GTC
ala ala gln phe phe gly his thr his val asp glu phe glu val 465
TTC TAT GAT GAA GAG ACT CTG AGC CGG CCG CTG GCT GTA GCC TTC
phe tyr asp glu glu thr leu ser arg pro leu ala val ala phe 480
CTG GCA CCC AGT GCA ACT ACC TAC ATC GGC CTT AAT CCT GGT TAC
leu ala pro ser ala thr thr tyr ile gly leu asn pro gly tyr 495
CGT GTG TAC CAA ATA GAT GGA AAC TAC TCC GGG AGC TCT CAC GTG
arg val tyr gln ile asp gly asn tyr ser gly ser ser his val 510
GTC CTG GAC CAT GAG ACC TAC ATC CTG AAT CTG ACC CAG GCA AAC
val leu asp his glu thr tyr ile leu asn leu thr gln ala asn 525
ATA CCG GGA GCC ATA CCG CAC TGG CAG CTT CTC TAC AGG GCT CGA
ile pro gly ala ile pro his trp gln leu leu tyr arg ala arg 540
GAA ACC TAT GGG CTG CCC AAC ACA CTG CCT ACC GCC TGG CAC AAC
glu thr tyr gly leu pro asn thr leu pro thr ala trp his asn 555
CTG GTA TAT CGC ATG CGG GGC GAC ATG CAA CTT TTC CAG ACC TTC
leu val tyr arg met arg gly asp met gln leu phe gln thr phe 570
TGG TTT CTC TAC CAT AAG GGC CAC CCA CCC TCG GAG CCC TGT GGC
trp phe leu tyr his lys gly his pro pro ser glu pro cys gly 585
ACG CCC TGC CGT CTG GCT ACT CTT TGT GCC CAG CTC TCT GCC CGT
thr pro cys arg leu ala thr leu cys ala gln leu ser ala arg 600
GCT GAC AGC CCT GCT CTG TGC CGC CAC CTG ATG CCA GAT GGG AGC
ala asp ser pro ala leu cys arg his leu met pro asp gly ser 615
CTC CCA GAG GCC CAG AGC CTG TGG CCA AGG CCA CTG TTT TGC TAG
leu pro glu ala gln ser leu trp pro arg pro leu phe cys ter 630
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