Рис. HEXA seq.
Нуклеотидная и аминокислотная последовательности
гексозаминидазы А (hexosaminidase A; HEXA) человека.
ATG ACA AGC TCC AGG CTT TGG TTT TCG CTG CTG CTG GCG GCA GCG
met thr ser ser arg leu trp phe ser leu leu leu ala ala ala 15
TTC GCA GGA CGG GCG ACG GCC CTC TGG CCC TGG CCT CAG AAC TTC
phe ala gly arg ala thr ala leu trp pro trp pro gln asn phe 30
CAA ACC TCC GAC CAG CGC TAC GTC CTT TAC CCG AAC AAC TTT CAA
gln thr ser asp gln arg tyr val leu tyr pro asn asn phe gln 45
TTC CAG TAC GAT GTC AGC TCG GCC GCG CAG CCC GGC TGC TCA GTC
phe gln tyr asp val ser ser ala ala gln pro gly cys ser val 60
CTC GAC GAG GCC TTC CAG CGC TAT CGT GAC CTG CTT TTC GGT TCC
leu asp glu ala phe gln arg tyr arg asp leu leu phe gly ser 75
GGG TCT TGG CCC CGT CCT TAC CTC ACA GGG AAA CGG CAT ACA CTG
gly ser trp pro arg pro tyr leu thr gly lys arg his thr leu 90
GAG AAG AAT GTG TTG GTT GTC TCT GTA GTC ACA CCT GGA TGT AAC
glu lys asn val leu val val ser val val thr pro gly cys asn 105
CAG CTT CCT ACT TTG GAG TCA GTG GAG AAT TAT ACC CTG ACC ATA
gln leu pro thr leu glu ser val glu asn tyr thr leu thr ile 120
AAT GAT GAC CAG TGT TTA CTC CTC TCT GAG ACT GTC TGG GGA GCT
asn asp asp gln cys leu leu leu ser glu thr val trp gly ala 135
CTC CGA GGT CTG GAG ACT TTT AGC CAG CTT GTT TGG AAA TCT GCT
leu arg gly leu glu thr phe ser gln leu val trp lys ser ala 150
GAG GGC ACA TTC TTT ATC AAC AAG ACT GAG ATT GAG GAC TTT CCC
glu gly thr phe phe ile asn lys thr glu ile glu asp phe pro 165
CGC TTT CCT CAC CGG GGC TTG CTG TTG GAT ACA TCT CGC CAT TAC
arg phe pro his arg gly leu leu leu asp thr ser arg his tyr 180
CTG CCA CTC TCT AGC ATC CTG GAC ACT CTG GAT GTC ATG GCG TAC
leu pro leu ser ser ile leu asp thr leu asp val met ala tyr 195
AAT AAA TTG AAC GTG TTC CAC TGG CAT CTG GTA GAT GAT CCT TCC
asn lys leu asn val phe his trp his leu val asp asp pro ser 210
TTC CCA TAT GAG AGC TTC ACT TTT CCA GAG CTC ATG AGA AAG GGG
phe pro tyr glu ser phe thr phe pro glu leu met arg lys gly 225
TCC TAC AAC CCT GTC ACC CAC ATC TAC ACA GCA CAG GAT GTG AAG
ser tyr asn pro val thr his ile tyr thr ala gln asp val lys 240
GAG GTC ATT GAA TAC GCA CGG CTC CGG GGT ATC CGT GTG CTT GCA
glu val ile glu tyr ala arg leu arg gly ile arg val leu ala 255
GAG TTT GAC ACT CCT GGC CAC ACT TTG TCC TGG GGA CCA GGT ATC
glu phe asp thr pro gly his thr leu ser trp gly pro gly ile 270
CCT GGA TTA CTG ACT CCT TGC TAC TCT GGG TCT GAG CCC TCT GGC
pro gly leu leu thr pro cys tyr ser gly ser glu pro ser gly 285
ACC TTT GGA CCA GTG AAT CCC AGT CTC AAT AAT ACC TAT GAG TTC
thr phe gly pro val asn pro ser leu asn asn thr tyr glu phe 300
ATG AGC ACA TTC TTC TTA GAA GTC AGC TCT GTC TTC CCA GAT TTT
met ser thr phe phe leu glu val ser ser val phe pro asp phe 315
TAT CTT CAT CTT GGA GGA GAT GAG GTT GAT TTC ACC TGC TGG AAG
tyr leu his leu gly gly asp glu val asp phe thr cys trp lys 330
TCC AAC CCA GAG ATC CAG GAC TTT ATG AGG AAG AAA GGC TTC GGT
ser asn pro glu ile gln his phe met arg lys lys gly phe gly 345
GAG GAC TTC AAG CAG CTG GAG TCC TTC TAC ATC CAG ACG CTG CTG
glu asp phe lys gln leu glu ser phe tyr ile gln thr leu leu 360
GAC ATC GTC TCT TCT TAT GGC AAG GGC TAT GTG GTG TGG CAG GAG
asp ile val ser ser tyr gly lys gly tyr val val trp gln glu 375
GTG TTT GAT AAT AAA GTA AAG ATT CAG CCA GAC ACA ATC ATA CAG
val phe asp asn lys val lys ile gln pro asp thr ile ile gln 390
GTG TGG CGA GAG GAT ATT CCA GTG AAC TAT ATG AAG GAG CTG GAA
val trp arg glu asp ile pro val asn tyr met lys glu leu glu 405
CTG GTC ACC AAG GCC GGC TTC CGG GCC CTT CTC TCT GCC CCC TGG
leu val thr lys ala gly phe arg ala leu leu ser ala pro trp 420
TAC CTG AAC CGT ATA TCC TAT GGC CCT GAC TGG AAG GAT TTC TAC
tyr leu asn arg ile ser tyr gly pro asp trp lys asp phe tyr 435
GTA GTG GAA CCC CTG GCA TTT GAA GGT ACC CCT GAG CAG AAG GCT
val val glu pro leu ala phe glu gly thr pro glu gln lys ala 450
CTG GTG ATT GGT GGA GAG GCT TGT ATG TGG GGA GAA TAT GTG GAC
leu val ile gly gly glu ala cys met trp gly glu tyr val asp 465
AAC ACA AAC CTG GTC CCC AGG CTC TGG CCC AGA GCA GGG GCT GTT
asn thr asn leu val pro arg leu trp pro arg ala gly ala val 480
GCC GAA AGG CTG TGG AGC AAC AAG TTG ACA TCT GAC CTG ACA TTT
ala glu arg leu trp ser asn lys leu thr ser asp leu thr phe 495
GCC TAT GAA CGT TTG TCA CAC TTC CGC TGT GAG TTG CTG AGG CGA
ala tyr glu arg leu ser his phe arg cys glu leu leu arg arg 510
GGT GTC CAG GCC CAA CCC CTC AAT GTA GGC TTC TGT GAG CAG GAG
gly val gln ala gln pro leu asn val gly phe cys glu gln glu 525
TTT GAA CAG ACC TGA
phe glu gln thr ter
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