Рис. 13 pat
Рис. 13. Нуклеотидная и аминокислотная последовательности
гомогентизиназы (Homogentisate 1,2 dioxygenase)
человека
ATG GCT GAG TTA AAG TAC ATT TCT GGA TTT GGG AAT GAG TGT TCT 15
met ala glu leu lys tyr ile ser gly phe gly asn glu cys ser
TCA GAG GAT CCT CGC TGC CCA GGT TCC CTG CCA GAA GGA CAG AAT 30
ser glu asp pro arg cys pro gly ser leu pro glu gly gln asn
AAT CCT CAG GTC TGC CCC TAC AAT CTC TAT GCT GAG CAG CTC TCA 45
asn pro gln val cys pro tyr asn leu tyr ala glu gln leu ser
GGA TCG GCT TTC ACT TGT CCA CGG AGC ACC AAT AAG AGA AGC TGG 60
gly ser ala phe thr cys pro arg ser thr asn lys arg ser trp
CTG TAT AGG ATT CTA CCT TCA GTT TCT CAC AAG CCC TTT GAA TCC 75
leu tyr arg ile leu pro ser val ser his lys pro phe glu ser
ATT GAC GAA GGC CAT GTC ACT CAC AAC TGG GAT GAA GTT GAT CCT 90
ile asp glu gly his val thr his asn trp asp glu val asp pro
GAT CCT AAC CAG CTT AGA TGG AAA CCA TTT GAG ATT CCA AAA GCA 105
asp pro asn gln leu arg trp lys pro phe glu ile pro lys ala
TCT CAG AAG AAA GTA GAC TTT GTG AGT GGC CTG CAT ACC TTG TGT 120
ser gln lys lys val asp phe val ser gly leu his thr leu cys
GGA GCT GGA GAC ATA AAG TCT AAC AAT GGG CTT GCT ATC CAC ATT 135
gly ala gly asp ile lys ser asn asn gly leu ala ile his ile
TTC CTC TGC AAT ACC TCC ATG GAG AAC AGA TGC TTT TAC AAT TCA 150
phe leu cys asn thr ser met glu asn arg cys phe tyr asn ser
GAT GGG GAC TTC TTG ATT GTT CCG CAG AAA GGG AAC CTT CTC ATT 165
asp gly asp phe leu ile val pro gln lys gly asn leu leu ile
TAC ACC GAG TTT GGC AAG ATG CTT GTA CAG CCC AAT GAG ATC TGC 180
tyr thr glu phe gly lys met leu val gln pro asn glu ile cys
GTC ATT CAG AGA GGA ATG CGG TTC AGC ATA GAT GTC TTT GAG GAG 195
val ile gln arg gly met arg phe ser ile asp val phe glu glu
ACC AGG GGC TAC ATC TTG GAG GTC TAT GGT GTC CAC TTT GAG TTA 210
thr arg gly tyr ile leu glu val tyr gly val his phe glu leu
CCT GAC CTT GGA CCA ATT GGG GCC AAT GGC TTG GCC AAT CCT CGT 225
pro asp leu gly pro ile gly ala asn gly leu ala asn pro arg
GAT TTC TTG ATA CCC ATT GCC TGG TAT GAG GAT CGC CAA GTA CCA 240
asp phe leu ile pro ile ala trp tyr glu asp arg gln val pro
GGT GGT TAC ACG GTC ATT AAT AAA TAC CAG GGC AAG CTG TTT GCT 255
gly gly tyr thr val ile asn lys tyr gln gly lys leu phe ala
GCC AAA CAG GAT GTC TCC CCG TTC AAT GTT GTG GCC TGG CAC GGG 270
ala lys gln asp val ser pro phe asn val val ala trp his gly
AAT TAT ACA CCC TAC AAG TAC AAC CTG AAG AAT TTC ATG GTT ATC 285
asn tyr thr pro tyr lys tyr asn leu lys asn phe met val ile
AAC TCA GTG GCC TTT GAC CAT GCA GAC CCA TCC ATT TTC ACA GTA 300
asn ser val ala phe asp his ala asp pro ser ile phe thr val
TTG ACT GCT AAG TCT GTC CGC CCT GGA GTG GCC ATT GCT GAT TTT 315
leu thr ala lys ser val arg pro gly val ala ile ala asp phe
GTC ATC TTC CCA CCT CGA TGG GGG GTT GCT GAT AAG ACC TTC AGG 330
val ile phe pro pro arg trp gly val ala asp lys thr phe arg
CCT CCT TAT TAC CAT AGG AAC TGC ATG AGT GAG TTC ATG GGA CTC 345
pro pro tyr tyr his arg asn cys met ser glu phe met gly leu
ATC CGA GGT CAC TAT GAG GCA AAG CAA GGT GGG TTC CTG CCA GGG 360
ile arg gly his tyr glu ala lys gln gly gly phe leu pro gly
GGA GGG AGT CTA CAC AGC ACA ATG ACC CCC CAT GGA CCT GAT GCT 375
gly gly ser leu his ser thr met thr pro his gly pro asp ala
GAC TGC TTT GAG AAG GCC AGC AAG GTC AAG CTG GCA CCT GAG AGG 390
asp cys phe glu lys ala ser lys val lys leu ala pro gln arg
ATT GCC GAT GGC ACC ATG GCA TTT ATG TTT GAA TCA TCT TTA AGT 405
ile ala asp gly thr met ala phe met phe glu ser ser leu ser
CTG GCG GTC ACA AAG TGG GGA CTC AAG GCC TCC AGG TGT TTG GAT 420
leu ala val thr lys trp gly leu lys ala ser arg cys leu asp
GAG AAC TAC CAC AAG TGC TGG GAG CCA CTC AAG AGC CAC TTC ACT 435
glu asn tyr his lys cys trp glu pro leu lys ser his phe thr
CCC AAC TCC AGG AAC CCA GCA GAA CCT AAT TGA
pro asn ser arg asn pro ala glu pro asn ter
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