Рис. 22 pat
Нуклеотидная и аминокислотная последовательности липоамид дегидрoгеназы (DLD) человека ggaggggagaccttggc ggacggcggagccccagcggaggtgaaagtattggcggaaaggaaaatacagcggaaaa atg cag agc tgg agt cgt gtg tac tgc tcc ttg gcc aag aga ggc met gln ser trp ser arg val tyr cys ser leu ala lys arg gly 15 cat ttc aat cga ata tct cat ggc cta cag gga ctt tct gca gtg his phe asn arg ile ser his gly leu gln gly leu ser ala val 30 cct ctg aga act tac gca gat cag ccg att gat gct gat gta aca pro leu arg thr tyr ala asp gln pro ile asp ala asp val thr 45 gtt ata ggt tct ggt cct gga gga tat gtt gct gct att aaa gct val ile gly ser gly pro gly gly tyr val ala ala ile lys ala 60 gcc cag tta ggc ttc aag aca gtc tgc att gag aaa aat gaa aca ala gln leu gly phe lys thr val cys ile glu lys asn glu thr 75 ctt ggt gga aca tgc ttg aat gtt ggt tgt att cct tct aag gct leu gly gly thr cys leu asn val gly cys ile pro ser lys ala 90 tta ttg aac aac tct cat tat tac cat atg gcc cat gga aca gat leu leu asn asn ser his tyr tyr his met ala his gly thr asp 105 ttt gca tct aga gga att gaa atg tcc gaa gtt cgc ttg aat tta phe ala ser arg gly ile glu met ser glu val arg leu asn leu 120 gac aag atg atg gag cag aag agt act gca gta aaa gct tta aca asp lys met met glu gln lys ser thr ala val lys ala leu thr 135 ggt gga att gcc cac tta ttc aaa cag aat aag gtt gtt cat gtc gly gly ile ala his leu phe lys gln asn lys val val his val 150 aat gga tat gga aag ata act ggc aaa aat caa gtc act gct acg asn gly tyr gly lys ile thr gly lys asn gln val thr ala thr 165 aaa gct gat ggc ggc act cag gtt att gat aca aag aac att ctt lys ala asp gly gly thr gln val ile asp thr lys asn ile leu 180 ata gcc acg ggt tca gaa gtt act cct ttt cct gga atc acg ata ile ala thr gly ser glu val thr pro phe pro gly ile thr ile 195 gat gaa gat aca ata gtg tca tct aca ggt gct tta tct tta aaa asp glu asp thr ile val ser ser thr gly ala leu ser leu lys 210 aaa gtt cca gaa aag atg gtt gtt att ggt gca gga gta ata ggt lys val pro glu lys met val val ile gly ala gly val ile gly 225 gta gaa ttg ggt tca gtt tgg caa aga ctt ggt gca gat gtg aca val glu leu gly ser val trp gln arg leu gly ala asp val thr 240 gca gtt gaa ttt tta ggt cat gta ggt gga gtt gga att gat atg ala val glu phe leu gly his val gly gly val gly ile asp met 255 gag ata tct aaa aac ttt caa cgc atc ctt caa aaa cag ggg ttt glu ile ser lys asn phe gln arg ile leu gln lys gln gly phe 270 aaa ttt aaa ttg aat aca aag gtt act ggt gct acc aag aag tca lys phe lys leu asn thr lys val thr gly ala thr lys lys ser 285 gat gga aaa att gat gtt tct att gaa gct gct tct ggt ggt aaa asp gly lys ile asp val ser ile glu ala ala ser gly gly lys 300 gct gaa gtt atc act tgt gat gta ctc ttg gtt tgc att ggc cga ala glu val ile thr cys asp val leu leu val cys ile gly arg 315 cga ccc ttt act aag aat ttg gga cta gaa gag ctg gga att gaa arg pro phe thr lys asn leu gly leu glu glu leu gly ile glu 330 cta gat cct aga ggt aga att cca gtc aat acc aga ttt caa act leu asp pro arg gly arg ile pro val asn thr arg phe gln thr 345 aaa att cca aat atc tat gcc att ggt gat gta gtt gct ggt cca lys ile pro asn ile tyr ala ile gly asp val val ala gly pro 360 atg ctg gct cac aaa gca gag gat gaa ggc att atc tgt gtt gaa met leu ala his lys ala glu asp glu gly ile ile cys val glu 375 gga atg gct ggt ggt gct gtg cac att gac tac aat tgt gtg cca gly met ala gly gly ala val his ile asp tyr asn cys val pro 390 tca gtg att tac aca cac cct gaa gtt gct tgg gtt ggc aaa tca ser val ile tyr thr his pro glu val ala trp val gly lys ser 405 gaa gag cag ttg aaa gaa gag ggt att gag tac aaa gtt ggg aaa glu glu gln leu lys glu glu gly ile glu tyr lys val gly lys 420 ttc cca ttt gct gct aac agc aga gct aag aca aat gct gac aca phe pro phe ala ala asn ser arg ala lys thr asn ala asp thr 435 gat ggc atg gtg aag atc ctt ggg cag aaa tcg aca gac aga gta asp gly met val lys ile leu gly gln lys ser thr asp arg val 450 ctg gga gca cat att ctt gga cca ggt gct gga gaa atg gta aat leu gly ala his ile leu gly pro gly ala gly glu met val asn 465 gaa gct gct ctt gct ttg gaa tat gga gca tcc tgt gaa gat ata glu ala ala leu ala leu glu tyr gly ala ser cys glu asp ile 480 gct aga gtc tgt cat gca cat ccg acc tta tca gaa gct ttt aga ala arg val cys his ala his pro thr leu ser glu ala phe arg 495 gaa gca aat ctt gct gcg tca ttt ggc aaa tca atc aac ttt tga glu ala asn leu ala ala ser phe gly lys ser ile asn phe ter 510 attagaagattatatatttttttttctgaaatttcctgggagcttttgtagaagtcaca ttcctgaacaggatattctcacagctccaagaatttctaggactgaattatgaaacttt tggaaggtatttaataggtttggacaaaatggaatactcttatatctatattttacata aatttagtattttgtttcagtgcactaatatgtaagacaaaaaggactacttattgtag tcatcctggaatatctccgtcaactcatattttcatgctgttcatgaaagattcaatgc ccctgaatttaaatagctcttttctctgatacagaaaagttgaattttacatggctgga gctagaatttgatatgtgaacagttgtgtttgaagcacagtgatcaagttatttttaat ttggttttcacattggaaacaagtcagtcattcagatatgattcaaatgtctataaacc aaactgatgtaagtaaatggtctctcacttgttttatttaacctctaaattctttcatt ttaggggtagcatttgtgttgaagaggttttaaagcttccattgttgtctgcaactctg aagggtaattatatagttacccaaattaagagagtctatttacggaactcaaatacgtg ggcattcaaatgtattacagtggggaatgaagatactgaaataaacgtcttaaatattc
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