Рис. 16 pat


Нуклеотидная и аминокислотная

последовательности метилмалонил Ко-А

мутазы (MUT) человека.

agtccaaaacaggcctaccagtcagttcttatttctattgggtgtttccatgctccacc

atg tta aga gct aag aat cag ctt ttt tta ctt tca cct cat tac
met leu arg ala lys asn gln leu phe leu leu ser pro his tyr  15

ctg agg cag gta aaa gaa tca tca ggc tcc agg ctc ata cag caa
leu arg gln val lys glu ser ser gly ser arg leu ile gln gln  30

cga ctt cta cac cag caa cag ccc ctt cac cca gaa tgg gct gcc
arg leu leu his gln gln gln pro leu his pro glu trp ala ala  45

ctg gct aaa aag cag ctg aaa ggc aaa aac cca gaa gac cta ata
leu ala lys lys gln leu lys gly lys asn pro glu asp leu ile  60

tgg cac acc ccg gaa ggg atc tct ata aaa ccc ttg tat tcc aag
trp his thr pro glu gly ile ser ile lys pro leu tyr ser lys  75

aga gat act atg gac tta cct gaa gaa ctt cca gga gtg aag cca
arg asp thr met asp leu pro glu glu leu pro gly val lys pro  90

ttc aca cgt gga cca tat cct acc atg tat acc ttt agg ccc tgg
phe thr arg gly pro tyr pro thr met tyr thr phe arg pro trp 105

acc atc cgc cag tat gct ggt ttt agt act gtg gaa gaa agc aat
thr ile arg gln tyr ala gly phe ser thr val glu glu aer asn 120

aag ttc tat aag gac aac att aag gct ggt cag cag gga tta tca
lys phe tyr lys asp asn ile lys ala gly gln gln gly leu ser 135

gtt gcc ttt gat ctg gcg aca cat cgt ggc tat gat tca gac aac
val ala phe asp leu ala thr his arg gly tyr asp ser asp asn 150

cct cga gtt cgt ggt gat gtt gga atg gct gga gtt gct att gac
pro arg leu arg gly asp val gly met ala gly val ala ile asp 165

act gtg gaa gat acc aaa att ctt ttt gat gga att cct tta gaa
thr val glu asp thr lys ile leu phe asp gly ile pro leu glu 180

aaa atg tca gtt tcc atg act atg aat gga gca gtt att cca gtt
lys met ser val ser met thr met asn gly ala val ile pro val 195

ctt gca aat ttt ata gta act gga gaa gaa caa ggt gta cct aaa
leu ala asn phe ile val thr gly glu glu gln gly val pro lys 210

gag aaa ctt act ggt acc atc caa aat gat ata cta aag gaa ttt
glu lys leu thr gly thr ile gln asn asp ile leu lys glu phe 225

atg gtt cga aat aca tac att ttt cct cca gaa cca tcc atg aaa
met val arg asn thr tyr ile phe pro pro asp pro ser met lys 240

att att gct gac ata ttt gaa tat aca gca aag cac atg cca aaa
ile ile ala asp ile phe glu tyr thr ala lys his met pro lys 255

ttt aat tca att tca att agt gga tac cat atg cag gaa gca ggg
phe asn ser ile ser ile ser gly tyr his met gln glu ala gly 270

gct gat gcc att ctg gag ctg gcc tat act tta gca gat gga ttg
ala asp ala ile leu glu leu ala tyr thr leu ala asp gly leu 285

gag tac tct aga act gga ctc cag gct ggc ctg aca att gat gaa
glu tyr ser arg thr gly leu gln ala gly leu thr ile asp glu 300

ttt gca cca agg ttg tct ttc ttc tgg gga att gga atg aat ttc
phe ala pro arg leu ser phe phe trp gly ile gly met asn phe 315

tat atg gaa ata gca aag atg aga gct ggt aga aga ctc tgg gct
his met glu ile ala lys met arg ala gly arg arg leu trp ala 330

cac tta ata gag aaa atg ttt cag cct aaa aac tca aaa tct ctt
his leu ile glu lys met phe gln pro lys asn ser lys ser leu 345

ctt cta aga gca cac tgt cag aca tct gga tgg tca ctt act gag
leu leu arg ala his cys gln thr ser gly trp ser leu thr glu 360

cag gat ccc tac aat aat att gtc cgt act gca ata gaa gca atg
gln asp pro tyr asn asn ile val arg thr ala ile glu ala met 375

gca gca gta ttt gga ggg act cag tct ttg cac aca aat tct ttt
ala ala val phe gly gly thr gln ser leu his thr asn ser phe 390

gat gaa gct ttg ggt ttg cca act gtg aaa agt gct cga att gcc
asp glu ala leu gly leu pro thr val lys ser ala arg ile ala 405

agg aac aca caa atc atc att caa gaa gaa tct ggg att ccc aaa
arg asn thr gln ile ile ile gln glu glu ser gly ile pro lys 420

gtg gct gat cct tgg gga ggt tct tac atg atg gaa tgt ctc aca
val ala asp pro trp gly gly ser tyr met met glu cys leu thr 435

aag ctc att aat gaa att gaa gaa atg ggt gga atg gcc aaa gct
lys leu ile asn glu ile glu glu met gly gly met ala lys ala 450

gta gct gag gga ata cct aaa ctt cga att gaa gaa tgt gct gcc
val ala glu gly ile pro lys leu arg ile glu glu cys ala ala 465

cga aga caa gct aga ata gat tct ggt tct gaa gta att gtt gga
arg arg gln ala arg ile asp ser gly ser glu val ile val gly 480

gta aat aag tac cag ttg gaa aaa gaa gac gct gta gaa gtt ctg
val asn lys tyr gln leu glu lys glu asp ala val glu val leu 495

gca att gat aat act tca gtg cga aac agg cag att gaa aaa ctt
ala thr asp asn thr ser val arg asn arg gln ile gly lys leu 510

aag aag atc aaa tcc agc agg gat caa gct ttg gct gaa cat tgt
lys lys ile lys ser ser arg asp gln ala leu ala glu his cys 525

ctt gct gca cta acc gaa tgt gct gct agc gga gat gga aat atc
leu ala ala leu thr glu cys ala ala ser gly asp gly asn ile 540

ctg gct ctt gca gtg gat gca tct cgg gca aga tgt aca gtg gga
leu ala leu ala val asp ala ser arg ala arg cys thr val gly 555

gaa atc aca gat gcc ctg aaa aag gta ttt ggt gaa cat aaa gcg
glu ile thr asp ala leu lys lys val phe gly glu his lys ala 570

aat gat cga atg gtg agt gga gca tat cgc cag gaa ttt gga gaa
asn asp arg met val ser gly ala tyr arg gln glu tyr gly glu 585

agt aaa gag ata aca tct gct atc aag agg gtt cat aaa ttc atg
ser lys glu ile thr ser ala ile lys arg val his lys phe met 600

gaa cgt gaa ggt cgc aga cct cgt ctt ctt gta gca aaa atg gga
glu arg glu gly arg arg pro arg leu leu val ala lys met gly 615

caa gat ggc cat gac aga gga gca aaa gtt att gct aca gga ttt
gln asp gly his asp arg gly ala lys val ile ala thr gly phe 630

gct gat ctt ggt ttt gat gtg gac ata ggc cct ctt ttc cag act
ala asp leu gly phe asp val asp ile gly pro leu phe gln thr 645

cct cgt gaa gtg gcc cag cag gct gtg gat gcg gat gtg cat gct
pro arg glu val ala gln gln ala val asp ala asp val his ala 660

gtg ggc gta agc acc ctc gct gct ggt cat aaa acc cta gtt cct
val gly val ser thr leu ala ala gly his lys thr leu val pro 675

gaa ctc atc aaa gaa ctt aac tcc ctt gga cgg cca gat att ctt
glu leu ile lys glu leu asn ser leu gly arg pro asp ile leu 690

gtc atg tgt gga ggg gtg ata cca cct cag gat tat gaa ttt ctg
val met cys gly gly val ile pro pro gln asp tyr glu phe leu 705

ttt gaa gtt ggt gtt tcc aat gta ttt ggt cct ggg act cga att
phe glu val gly val ser asn val phe gly pro gly thr arg ile 720

cca aag gct gcc gtt cag gtg ctt gat gat att gag aag tgt ttg
pro lys ala ala val gln val leu asp asp ile glu lys cys leu 735

gaa aag aag cag caa tct gta taa tatcctctttttgttttagcttttgtct
glu lys lys gln gln ser val

aaaatattattttagttatgatcaaagaagagagtaaagctatgtcttcaatttaatttc
aatacctgatttgtactttccttgaaagctttactttaaaataccttacttataggcctg
gtgtcatgctataagtatgtacatacagtttcacttcaaaaataaaaaaaaatccctaaa
aactctctatactctctataacaatactttatcaagaactctggacaatggtattatttt
taaaaatcatggtgatgtatttattagaatgtttcttataaatctctttcatttttatat
taagaattaaactgtacctaaaaaaactctgactattcccatttctcagtttagcattac
attgtcttgagcaccagaaaataaaatccatatattaattaaaacctatcttgaaaaaaa
aaaaaaaaaaaaaaaaaaaaa


Смотрите также:

  • ГЕН MUT (Метилмолоновая ацидемия): cтроение