Рис. 17
Нуклеотидная и аминокислотная
последовательности альфа субъединицы
пропионил КоА карбоксилазы (PCCA) человека
cccgctggtcgctgccggacggcgtgggcggtggccgcgcagcagctg
atg ctg agc gcg gcg ctg cgg acc ctg aag cat gtt ctg tac tat
met leu ser ala ala leu arg thr leu lys his val leu tyr tyr 15
tca aga cag tgc tta atg gtg tcc cgt aat ctt ggt tca gtg gga
ser arg gln cys leu met val ser arg asn leu gly ser val gly 30
tat gat cct aat gaa aaa act ttt gat aaa att ctt gtt gct aat
tyr asp pro asn glu lys thr phe asp lys ile leu val ala asn 45
aga gga gaa att gca tgt cgg gtt att aga act tgc aag aag atg
arg gly glu ile ala cys arg val ile arg thr cys lys lys met 60
ggc att aag aca gtt gcc atc cac agt gat gtt gat gct agt tct
gly ile lys thr val ala ile his ser asp val asp ala ser ser 75
gtt cat gtg aaa atg gcg gat gag gct gtc tgt gtt ggc cca gct
val his val lys met ala asp glu ala val cys val gly pro ala 90
ccc acc agt aaa agc tac ctc aac atg gat gcc atc atg gaa gcc
pro thr ser lys ser tyr leu asn met asp ala ile met glu ala 105
att aag aaa acc agg gcc caa gct gta cat cca ggt tat gga ttc
ile lys lys thr arg ala gln ala val his pro gly tyr gly phe 120
ctt tca gaa aac aaa gaa ttt gcc aga tgt ttg gca gca gaa gat
leu ser glu asn lys glu phe ala arg cys leu ala ala glu asp 135
gtc gtt ttc att gga cct gac aca cat gct att caa gcc atg ggc
val val phe ile gly pro asp thr his ala ile gln ala met gly 150
gac aag att gaa agc aaa tta tta gct aag aaa gca gag gtt aat
asp lys ile glu ser lys leu leu ala lys lys ala glu val asn 165
aca atc cct ggc ttt gat gga gta gtc aag gat gca gaa gaa gct
thr ile pro gly phe asp gly val val lys asp ala glu glu ala 180
gtc aga att gca agg gaa att ggc tac cct gtc atg atc aag gcc
val arg ile ala arg glu ile gly tyr pro val met ile lys ala 195
tca gca ggt ggt ggt ggg aaa ggc atg cgc att gct tgg gat gat
ser ala gly gly gly gly lys gly met arg ile ala trp asp asp 210
gaa gag acc agg gat ggt ttt aga ttg tca tct caa gaa gct gct
glu glu thr arg asp gly phe arg leu ser ser gln glu ala ala 225
tct agt ttt ggc gat gat aga cta cta ata gaa aaa ttt att gat
ser ser phe gly asp asp arg leu leu ile glu lys phe ile asp 240
aat cct cgt cat ata gaa atc cag gtt cta ggt gat aaa cat ggg
asn pro arg his ile glu ile gln val leu gly asp lys his gly 255
aat gct tta tgg ctt aat gaa aga gag tgc tca att cag aga aga
asn ala leu trp leu asn glu arg glu cys ser ile gln arg arg 270
aat cag aag gtg gtg gag gaa gca cca agc att ttt ttg gat gcg
asn gln lys val val glu glu ala pro ser ile phe leu asp ala 285
gag act cga aga gcg atg gga gaa caa gct gta gct ctt gcc aga
glu thr arg arg ala met gly glu gln ala val ala leu ala arg 300
gca gta aaa tat tcc tct gct ggg acc gtg gag ttc ctt gtg gac
ala val lys tyr ser ser ala gly thr val glu phe leu val asp 315
tct aag aag aat ttt tat ttc ttg gaa atg aat aca aga ctc cag
ser lys lys asn phe tyr phe leu glu met asn thr arg leu gln 330
gtt gag cat cct gtc aca gaa tgc att act ggc ctg gac cta gtc
val glu his pro val thr glu cys ile thr gly leu asp leu val 345
cag gaa atg atc cgt gtt gct aag ggc tac cct ctc agg cac aaa
gln glu met ile arg val ala lys gly tyr pro leu arg his lys 360
caa gct gat att cgc atc aac ggc tgg gca gtt gaa tgt cgg gtt
gln ala asp ile arg ile asn gly trp ala val glu cys arg val 375
tat gct gag gac ccc tac aag tct ttt ggt tta cca tct att ggg
tyr ala glu asp pro tyr lys ser phe gly leu pro ser ile gly 390
aga ttg tct cag tac caa gaa ccg tta cat cta cct ggt gtc cga
arg leu ser gln tyr gln glu pro leu his leu pro gly val arg 405
gtg gac agt ggc atc caa cca gga agt gat att agc att tat tat
val asp ser gly ile gln pro gly ser asp ile ser ile tyr tyr 420
gat cct atg att tca aaa cta atc aca tat ggc tct gat aga act
asp pro met ile ser lys leu ile thr tyr gly ser asp arg thr 435
gag gca ctg aag aga atg gca gat gca ctg gat aac tat gtt att
glu ala leu lys arg met ala asp ala leu asp asn tyr val ile 450
cga ggt gtt aca cat aat att gca tta ctt cga gag gtg ata atc
arg gly val thr his asn ile ala leu leu arg glu val ile ile 465
aac tca cgc ttt gta aaa gga gac atc agc act aaa ttt ctc tcc
asn ser arg phe val lys gly asp ile ser thr lys phe leu ser 480
gat gtg tat cct gat ggc ttc aaa gga cac atg cta acc aag agt
asp val tyr pro asp gly phe lys gly his met leu thr lys ser 495
gag aag aac cag tta ttg gca ata gca tca tca ttg ttt gtg gca
glu lys asn gln leu leu ala ile ala ser ser leu phe val ala 510
ttc cag tta aga gca caa cat ttt caa gaa aat tca aga atg cct
phe gln leu arg ala gln his phe gln glu asn ser arg met pro 525
gtt att aaa cca gac ata gcc aac tgg gag ctc tca gta aaa ttg
val ile lys pro asp ile ala asn trp glu leu ser val lys leu 540
cat gat aaa gtt cat acc gta gta gca tca aac aat ggg tca gtg
his asp lys val his thr val val ala ser asn asn gly ser val 555
ttc tcg gtg gaa gtt gat ggg tcg aaa cta aat gtg acc agc acg
phe ser val glu val asp gly ser lys leu asn val thr ser thr 570
tgg aac ctg gct tcg ccc tta ttg tct gtc agc gtt gat ggc act
trp asn leu ala ser pro leu leu ser val ser val asp gly thr 585
cag agg act gtc cag tgt ctt tct cga gaa gca ggt gga aac atg
gln arg thr val gln cys leu ser arg glu ala gly gly asn met 600
agc att cag ttt ctt ggt aca gtg tac aag gtg aat atc tta acc
ser ile gln phe leu gly thr val tyr lys val asn ile leu thr 615
aga ctt gcc gca gaa ttg aac aaa ttt atg ctg gaa aaa gtg act
arg leu ala ala glu leu asn lys phe met leu glu lys val thr 630
gag gac aca agc agt gtt ctg cgt tcc ccg atg ccc gga gtg gtg
glu asp thr ser ser val leu arg ser pro met pro gly val val 645
gtg gcc gtc tct gtc aag cct gga gac gcg gta gca gaa ggt caa
val ala val ser val lys pro gly asp ala val ala glu gly gln 660
gaa att tgt gtg att gaa gcc atg aaa atg cag aat agt atg aca
glu ile cys val ile glu ala met lys met gln asn ser met thr 675
gct ggg aaa act ggc acg gtg aaa tct gtg cac tgt caa gct gga
ala gly lys thr gly thr val lys ser val his cys gln ala gly 690
gac aca gtt gga gaa ggg gat ctg ctc gtg gag ctg gaa tga agg
asp thr val gly glu gly asp leu leu val glu leu glu ter 703
atttataacctttcagtcatcacccaatttaattagccatttgcatgatgctttcacac
acaattgattcaagcattatacaggaacaccctgtgcagctacgtttacgtcgtcattt
attccacagagtcaagaccaatattctgccaaaaaatcaccaatggaaattttcatgat
ataaatacttgtactatagatgtacttctgctgtgagattccctagtgtcaaaattaaa
tcaataaaactgagcatttgtct
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