Рис. 14 pat
Нуклеотидная (кДНК) и аминокислотная
последовательности фумарилацетоацетат
гидролазы (FAH) человека
agtcctgctctccgcacgccaccttaggcccgcagccgtgccgggtgctcttcagc
atg tcc ttc atc ccg gtg gcc gag gat tcc gac ttc ccc atc cac
met ser phe ile pro val ala glu asp ser asp phe pro ile his 15
aac ctg ccc tac ggc gtc ttc tcg acc aga ggc gac cca aga ccg
asn leu pro tyr gly val phe ser thr arg gly asp pro arg pro 30
agg ata ggt gtg gcc att ggc gac cag atc ctg gac ctc agc atc
arg ile g;y val ala ile gly asp gln ile leu asp leu ser ile 45
atc aag cac ctc ttt act ggt cct gtc ctc tcc aaa cac cag gat
ile lys his leu phe thr gly pro val leu ser lys his gln asp 60
*
gtc ttc aat cag cct aca ctc aac agc ttc atg ggc ctg ggt cag
val phe asn gln pro thr leu asn ser phe met gly leu gly gln 75
gct gcc tgg aag gag gcg aga gtg ttc ttg cag aac ttg ctg tct
ala ala trp lys glu ala arg val phe leu gln asn leu leu ser 90
gtg agc caa gcc agg ctc aga gat gac acc gaa ctt cgg aag tgt
val ser gln ala arg leu arg asp asp thr glu leu arg lys cys 105
gca ttc atc tcc cag gct tct gcc acg atg cac ctt cca gcc acc
ala phe ile ser gln ala ser ala thr met his leu pro ala thr 120
ata gga gac tac aca gac ttc tat tcc tct cgg cag cat gct acc
ile gly asp tyr thr asp phe tyr ser ser arg gln his ala thr 135
aac gtc gga atc atg ttc agg gac aag gag aat gcg ttg atg cca
asn val gly ile met phe arg asp lys glu asn ala leu met pro 150
aat tgg ctg cac tta cca gtg ggc tac cat ggc cgt gcc tcc tct
asn trp leu his leu pro val gly tyr his gly arg ala ser ser 165
gtc gtg gtg tct ggc acc cca atc cga agg ccc atg gga cag atg
val val val ser gly thr pro ile arg arg pro met gly gln met 180
aaa cct gat gac tct aag cct ccc gta tat ggt gcc tgc aag ctc
lys pro asp asp ser lys pro pro val tyr gly ala cys lys leu 195
ttg gac atg gag ctg gaa atg gct ttt ttt gta ggc cct gga aac
leu asp met glu leu glu met ala phe phe val gly pro gly asn 210
aga ttg gga gag ccg atc ccc att tcc aag gcc cat gag cac att
arg leu gly glu pro ile pro ile ser lys ala his glu his ile 225
ttt gga atg gtc ctt atg aac gac tgg agt gca cga gac att cag
phe gly met val leu met asn asp trp ser ala arg asp ile gln 240
aag tgg gag tat gtc cct ctc ggg cca ttc ctt ggg aag agt ttt
lys trp glu tyr val pro leu gly pro phe leu gly lys ser phe 255
ggg acc act gtc tct ccg tgg gtg gtg ccc atg gat gct ctc atg
gly thr thr val ser pro trp val val pro met asp ala leu met 270
ccc ttt gct gtg ccc aac ccg aag cag gac ccc agg ccc ctg ccg
pro phe ala val pro asn pro lys gln asp pro arg pro leu pro 285
tat ctg tgc cat gac gag ccc tac aca ttt gac atc aac ctc tct
tyr leu cys his asp glu pro tyr thr phe asp ile asn leu ser 300
gtt aac ctg aaa gga gaa gga atg agc cag gcg gct acc ata tgc
val asn leu lys gly glu gly met ser gln ala ala thr ile cys 315
aag tcc aat ttt aag tac atg tac tgg acg atg ctg cag cag ctc
lys ser asn phe lys tyr met tyr trp thr met leu gln gln leu 330
act cac cac tct gtc aac ggc tgc aac ctg cgg ccg ggg gac ctc
thr his his ser val asn gly cys asn leu arg pro gly asp leu 345
ctg gct tct ggg acc atc agc ggg ccg gag cca gaa aac ttc ggc
leu ala ser gly thr ile ser gly pro glu pro glu asn phe gly 360
tcc atg ttg gaa ctg tcg tgg aag gga acg aag ccc ata gac ctg
ser met leu glu leu ser trp lys gly thr lys pro ile asp leu 375
ggg aat ggt cag acc agg aag ttt ctg ctg gac ggg gat gaa gtc
gly asn gly gln thr arg lys phe leu leu asp gly asp glu val 390
atc ata aca ggg tac tgc cag ggg gat ggt tac cgc atc ggc ttt
ile ile thr gly tyr cys gln gly asp gly tyr arg ile gly phe 405
ggc cag tgt gct gga aaa gtg ctg cct gct ctc ctg cca tca tga
gly gln cys ala gly lys val leu pro ala leu leu pro ser ter 420
gattttctctgctcttctggaaacaaagggctcaagcacccctttcaaccctgtgactg
gggtcctccctcgggctgtaggcctggtccgccattcagtgacaaataaagccattgtg
ctctgaggcctgc
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