Рис. CFTR seq
Нуклеотидная и аминокислотная последовательности
гена cystic fibrosis transmembrane conductance
regulator (CFT) человека.
ATG CAG AGG TCG CCT CTG GAA AAG GCC AGC GTT GTC TCC AAA CTT
met gln arg ser pro leu glu lys ala ser val val ser lys leu 15
TTT TTC AGC TGG ACC AGA CCA ATT TTG AGG AAA GGA TAC AGA CAG
phe phe ser trp thr arg pro ile leu arg lys gly tyr arg gln 30
CGC CTG GAA TTG TCA GAC ATA TAC CAA ATC CCT TCT GTT GAT TCT
arg leu glu leu ser asp ile tyr gln ile pro ser val asp ser 45
GCT GAC AAT CTA TCT GAA AAA TTG GAA AGA GAA TGG GAT AGA GAG
ala asp asn leu ser glu lys leu glu arg glu trp asp arg glu 60
CTG GCT TCA AAG AAA AAT CCT AAA CTC ATT AAT GCC CTT CGG CGA
leu ala ser lys lys asn pro lys leu ile asn ala leu arg arg 75
TGT TTT TTC TGG AGA TTT ATG TTC TAT GGA ATC TTT TTA TAT TTA
cys phe phe trp arg phe met phe tyr gly ile phe leu tyr leu 90
GGG GAA GTC ACC AAA GCA GTA CAG CCT CTC TTA CTG GGA AGA ATC
gly glu val thr lys ala val gln pro leu leu leu gly arg ile 105
ATA GCT TCC TAT GAC CCG GAT AAC AAG GAG GAA CGC TCT ATC GCG
ile ala ser tyr asp pro asp asn lys glu glu arg ser ile ala 120
ATT TAT CTA GGC ATA GGC TTA TGC CTT CTC TTT ATT GTG AGG ACA
ile tyr leu gly ile gly leu cys leu leu phe ile val arg thr 135
CTG CTC CTA CAC CCA GCC ATT TTT GGC CTT CAT CAC ATT GGA ATG
leu leu leu his pro ala ile phe gly leu his his ile gly met 150
CAG ATG AGA ATA GCT ATG TTT AGT TTG ATT TAT AAG AAG ACT TTA
gln met arg ile ala met phe ser leu ile tyr lys lys thr leu 165
AAG CTG TCA AGC CGT GTT CTA GAT AAA ATA AGT ATT GGA CAA CTT
lys leu ser ser arg val leu asp lys ile ser ile gly gln leu 180
GTT AGT CTC CTT TCC AAC AAC CTG AAC AAA TTT GAT GAA GGA CTT
val ser leu leu ser asn asn leu asn lys phe asp glu gly leu 195
GCA TTG GCA CAT TTC GTG TGG ATC GCT CCT TTG CAA GTG GCA CTC
ala leu ala his phe val trp ile ala pro leu gln val ala leu 210
CTC ATG GGG CTA ATC TGG GAG TTG TTA CAG GCG TCT GCC TTC TGT
leu met gly leu ile trp glu leu leu gln ala ser ala phe cys 225
GGA CTT GGT TTC CTG ATA GTC CTT GCC CTT TTT CAG GCT GGG CTA
gly leu gly phe leu ile val leu ala leu phe gln ala gly leu 240
GGG AGA ATG ATG ATG AAG TAC AGA GAT CAG AGA GCT GGG AAG ATC
gly arg met met met lys tyr arg asp gln arg ala gly lys ile 255
AGT GAA AGA CTT GTG ATT ACC TCA GAA ATG ATT GAA AAT ATC CAA
ser glu arg leu val ile thr ser glu met ile glu asn ile gln 270
TCT GTT AAG GCA TAC TGC TGG GAA GAA GCA ATG GAA AAA ATG ATT
ser val lys ala tyr cys trp glu glu ala met glu lys met ile 285
GAA AAC TTA AGA CAA ACA GAA CTG AAA CTG ACT CGG AAG GCA GCC
glu asn leu arg gln thr glu leu lys leu thr arg lys ala ala 300
TAT GTG AGA TAC TTC AAT AGC TCA GCC TTC TTC TTC TCA GGG TTC
tyr val arg tyr phe asn ser ser ala phe phe phe ser gly phe 315
TTT GTG GTG TTT TTA TCT GTG CTT CCC TAT GCA CTA ATC AAA GGA
phe val val phe leu ser val leu pro tyr ala leu ile lys gly 330
ATC ATC CTC CGG AAA ATA TTC ACC ACC ATC TCA TTC TGC ATT GTT
ile ile leu arg lys ile phe thr thr ile ser phe cys ile val 345
CTG CGC ATG GCG GTC ACT CGG CAA TTT CCC TGG GCT GTA CAA ACA
leu arg met ala val thr arg gln phe pro trp ala val gln thr 360
TGG TAT GAC TCT CTT GGA GCA ATA AAC AAA ATA CAG GAT TTC TTA
trp tyr asp ser leu gly ala ile asn lys ile gln asp phe leu 375
CAA AAG CAA GAA TAT AAG ACA TTG GAA TAT AAC TTA ACG ACT ACA
gln lys gln glu tyr lys thr leu glu tyr asn leu thr thr thr 390
GAA GTA GTG ATG GAG AAT GTA ACA GCC TTC TGG GAG GAG GGA TTT
glu val val met glu asn val thr ala phe trp glu glu gly phe 405
GGG GAA TTA TTT GAG AAA GCA AAA CAA AAC AAT AAC AAT AGA AAA
gly glu leu phe glu lys ala lys gln asn asn asn asn arg lys 420
ACT TCT AAT GGT GAT GAC AGC CTC TTC TTC AGT AAT TTC TCA CTT
thr ser asn gly asp asp ser leu phe phe ser asn phe ser leu 435
CTT GGT ACT CCT GTC CTG AAA GAT ATT AAT TTC AAG ATA GAA AGA
leu gly thr pro val leu lys asp ile asn phe lys ile glu arg 450
GGA CAG TTG TTG GCG GTT GCT GGA TCC ACT GGA GCA GGC AAG ACT
gly gln leu leu ala val ala gly ser thr gly ala gly lys thr 465
TCA CTT CTA ATG ATG ATT ATG GGA GAA CTG GAG CCT TCA GAG GGT
ser leu leu met met ile met gly glu leu glu pro ser glu gly 480
AAA ATT AAG CAC AGT GGA AGA ATT TCA TTC TGT TCT CAG TTT TCC
lys ile lys his ser gly arg ile ser phe cys ser gln phe ser 495
TGG ATT ATG CCT GGC ACC ATT AAA GAA AAT ATC ATC TTT GGT GTT
trp ile met pro gly thr ile lys glu asn ile ile phe gly val 510
TCC TAT GAT GAA TAT AGA TAC AGA AGC GTC ATC AAA GCA TGC CAA
ser tyr asp glu tyr arg tyr arg ser val ile lys ala cys gln 525
CTA GAA GAG GAC ATC TCC AAG TTT GCA GAG AAA GAC AAT ATA GTT
leu glu glu asp ile ser lys phe ala glu lys asp asn ile val 540
CTT GGA GAA GGT GGA ATC ACA CTG AGT GGA GGT CAA CGA GCA AGA
leu gly glu gly gly ile thr bleu ser gly gly gln arg ala arg 555
ATT TCT TTA GCA AGA GCA GTA TAC AAA GAT GCT GAT TTG TAT TTA
ile ser leu ala arg ala val tyr lys asp ala asp leu tyr leu 570
TTA GAC TCT CCT TTT GGA TAC CTA GAT GTT TTA ACA GAA AAA GAA
leu asp ser pro phe gly tyr leu asp val leu thr glu lys glu 585
ATA TTT GAA AGC TGT GTC TGT AAA CTG ATG GCT AAC AAA ACT AGG
ile phe glu ser cys val cys lys leu met ala asn lys thr arg 600
ATT TTG GTC ACT TCT AAA ATG GAA CAT TTA AAG AAA GCT GAC AAA
ile leu val thr ser lys met glu his leu lys lys ala asp lys 615
ATA TTA ATT TTG CAT GAA GGT AGC AGC TAT TTT TAT GGG ACA TTT
ile leu ile leu his glu gly ser ser tyr phe tyr gly thr phe 630
TCA GAA CTC CAA AAT CTA CAG CCA GAC TTT AGC TCA AAA CTC ATG
ser glu leu gln asn leu gln pro asp phe ser ser lys leu met 645
GGA TGT GAT TCT TTC GAC CAA TTT AGT GCA GAA AGA AGA AAT TCA
gly cys asp ser phe asp gln phe ser ala glu arg arg asn ser 660
ATC CTA ACT GAG ACC TTA CAC CGT TTC TCA TTA GAA GGA GAT GCT
ile leu thr glu thr leu his arg phe ser leu glu gly asp ala 675
CCT GTC TCC TGG ACA GAA ACA AAA AAA CAA TCT TTT AAA CAG ACT
pro val ser trp thr glu thr lys lys gln ser phe lys gln thr 690
GGA GAG TTT GGG GAA AAA AGG AAG AAT TCT ATT CTC AAT CCA ATC
gly glu phe gly glu lys arg lys asn ser ile leu asn pro ile 705
AAC TCT ATA CGA AAA TTT TCC ATT GTG CAA AAG ACT CCC TTA CAA
asn ser ile arg lys phe ser ile val gln lys thr pro leu gln 720
ATG AAT GGC ATC GAA GAG GAT TCT GAT GAG CCT TTA GAG AGA AGG
met asn gly ile glu glu asp ser asp glu pro leu glu arg arg 735
CTG TCC TTA GTA CCA GAT TCT GAG CAG GGA GAG GCG ATA CTG CCT
leu ser leu val pro asp ser glu gln gly glu ala ala leu pro 750
CGC ATC AGC GTG ATC AGC ACT GGC CCC ACG CTT CAG GCA CGA AGG
arg ile ser val ile ser thr gly pro thr leu gln ala arg arg 765
AGG CAG TCT GTC CTG AAC CTG ATG ACA CAC TCA GTT AAC CAA GGT
arg gln ser val leu asn leu met thr his ser val asn gln gly 780
CAG AAC ATT CAC CGA AAG ACA ACA GCA TCC ACA CGA AAA GTG TCA
gln asn ile his arg lys thr thr ala ser thr arg lys val ser 795
CTG GCC CCT CAG GCA AAC TTG ACT GAA CTG GAT ATA TAT TCA AGA
leu ala pro gln ala asn leu thr glu leu asp ile tyr ser arg 810
AGG TTA TCT CAA GAA ACT GGC TTG GAA ATA AGT GAA GAA ATT AAC
arg leu ser gln glu thr gly leu glu ile ser glu glu ile asn 825
GAA GAA GAC TTA AAG GAG TGC TTT TTT GAT GAT ATG GAG AGC ATA
glu glu asp leu lys glu cys phe phe asp asp met glu ser ile 840
CCA GCA GTG ACT ACA TGG AAC ACA TAC CTT CGA TAT ATT ACT GTC
pro ala val thr thr trp asn thr tyr leu arg tyr ile thr val 855
CAC AAG AGC TTA ATT TTT GTG CTA ATT TGG TGC TTA GTA ATT TTT
his lys ser leu ile phe val leu ile trp cys leu val ile phe 870
CTG GCA GAG GTG GCT GCT TCT TTG GTT GTG CTG TGG CTC CTT GGA
leu ala glu val ala ala ser leu val val leu trp leu leu gly 885
AAC ACT CCT CTT CAA GAC AAA GGG AAT AGT ACT CAT AGT AGA AAT
asn thr pro leu gln asp lys gly asn ser thr his ser arg asn 900
AAC AGC TAT GCA GTG ATT ATC ACC AGC ACC AGT TCG TAT TAT GTG
asn ser tyr ala val ile ile thr ser thr ser ser tyr tyr val 915
TTT TAC ATT TAC GTG GGA GTA GCC GAC ACT TTG CTT GCT ATG GGA
phe tyr ile tyr val gly val ala asp thr leu leu ala met gly 930
TTC TTC AGA GGT CTA CCA CTG GTG CAT ACT CTA ATC ACA GTG TCG
phe phe arg gly leu pro leu val his thr leu ile thr val ser 945
AAA ATT TTA CAC CAC AAA ATG TTA CAT TCT GTT CTT CAA GCA CCT
lys ile leu his his lys met leu his ser val leu gln ala pro 960
ATG TCA ACC CTC AAC ACG TTG AAA GCA GGT GGG ATT CTT AAT AGA
met ser thr leu asn thr leu lys ala gly gly ile leu asn arg 975
TTC TCC AAA GAT ATA GCA ATT TTG GAT GAC CTT CTG CCT CTT ACC
phe ser lys asp ile ala ile leu asp asp leu leu pro leu thr 990
ATA TTT GAC TTC ATC CAG TTG TTA TTA ATT GTG ATT GGA GCT ATA
ile phe asp phe ile gln leu leu leu ile val ile gly ala ile 1005
GCA GTT GTC GCA GTT TTA CAA CCC TAC ATC TTT GTT GCA ACA GTG
ala val val ala val leu gln pro tyr ile phe val ala thr val 1020
CCA GTG ATA GTG GCT TTT ATT ATG TTG AGA GCA TAT TTC CTC CAA
pro val ile val ala phe ile met leu arg ala tyr phe leu gln 1035
ACC TCA CAG CAA CTC AAA CAA CTG GAA TCT GAA GGC AGG AGT CCA
thr ser gln gln leu lys gln leu glu ser glu gly arg ser pro 1050
ATT TTC ACT CAT CTT GTT ACA AGC TTA AAA GGA CTA TGG ACA CTT
ile phe thr his leu val thr ser leu lys gly leu trp thr leu 1065
CGT GCC TTC GGA CGG CAG CCT TAC TTT GAA ACT CTG TTC CAC AAA
arg ala phe gly arg gln pro tyr phe glu thr leu phe his lys 1080
GCT CTG AAT TTA CAT ACT GCC AAC TGG TTC TTG TAC CTG TCA ACA
ala leu asn leu his thr ala asn trp phe leu tyr leu ser thr 1095
CTG CGC TGG TTC CAA ATG AGA ATA GAA ATG ATT TTT GTC ATC TTC
leu arg trp phe gln met arg ile glu met ile phe val ile phe 1110
TTC ATT GCT GTT ACC TTC ATT TCC ATT TTA ACA ACA GGA GAA GGA
phe ile ala val thr phe ile ser ile leu thr thr gly glu gly 1125
GAA GGA AGA GTT GGT ATT ATC CTG ACT TTA GCC ATG AAT ATC ATG
glu gly arg val gly ile ile leu thr leu ala met asn ile met 1140
AGT ACA TTG CAG TGG GCT GTA AAC TCC AGC ATA GAT GTG GAT AGC
ser thr leu gln trp ala val asn ser ser ile asp val asp ser 1155
TTG ATG CGA TCT GTG AGC CGA GTC TTT AAG TTC ATT GAC ATG CCA
leu met arg ser val ser arg val phe lys phe ile asp met pro 1170
ACA GAA GGT AAA CCT ACC AAG TCA ACC AAA CCA TAC AAG AAT GGC
thr glu gly lys pro thr lys ser thr lys pro tyr lys asn gly 1185
CAA CTC TCG AAA GTT ATG ATT ATT GAG AAT TCA CAC GTG AAG AAA
gln leu ser lys val met ile ile glu asn ser his val lys lys 1200
GAT GAC ATC TGG CCC TCA GGG GGC CAA ATG ACT GTC AAA GAT CTC
asp asp ile trp pro ser gly gly gln met thr val lys asp leu 1215
ACA GCA AAA TAC ACA GAA GGT GGA AAT GCC ATA TTA GAG AAC ATT
thr ala lys tyr thr glu gly gly asn ala ile leu glu asn ile 1230
TCC TTC TCA ATA AGT CCT GGC CAG AGG GTG GGC CTC TTG GGA AGA
ser phe ser ile ser pro gly gln arg val gly leu leu gly arg 1245
ACT GGA TCA GGG AAG AGT ACT TTG TTA TCA GCT TTT TTG AGA CTA
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