EC 6.3.2.17

 TETRAHYDROFOLATE:L-GLUTAMATE 'GAMMA'-LIGASE (ADP-FORMING)

: folylpolyglutamate synthase

: ATP + TETRAHYDROFOLYL-(n)-GLUTAMATE + L-GLUTAMATE =

ADP + ORTHOPHOSPHATE + TETRAHYDROFOLYL-(n+1)-GLUTAMATE TETRAHYDROFOLYL-(n)-GLUTAMATE - tetrahydrofolylpolyglutamate (), n ; TETRAHYDROFOLYL-(n+1)-GLUTAMATE n+1 .

(The enzymes from different sources (particularly eucaryotes versus procaryotes) have different substrate specificities with regard to one-carbon substituents and the number of glutamate residues present on the tetrahydrofolates)

GEM: 09q/FPGS (GAT- ) (9c-q34)

MIM: 136510

:

  • ( ):
  • .
  • THFGn+Glu+ATP=THFGn'+ADP+Pi