Gene: [00.0/CLAPA1] clathrin-associated/assembly/adaptor protein, large, alpha 1 (100kD);
|
FUN |
Adaptins are essential in dynamic processes of intracellular sorting, internalization, and transport of membrane-spanning receptors via 'clathrin-coated-vesicles'." |
|
MOP |
AP2 coat assembly protein complex of clathrin-coated vesicles is an heterotetramer composed of 2 large 100-kD components (alpha (GEM:00.0/CLAPA1, GEM:00.0/CLAPA2) or beta (GEM:17q1/CLAPB1, GEM:00.0/CLAPB2) subunits), 1 medium 50-kD component (GEM:03q28/CLAPM1), and 1 small component (GEM:00.0/CLAPS2, 17kD; see also GEM:00.0/CLAPS1, 19kD; GEM:12p13/CLAPS3; 22kD)." |
|
REL |
GEM:22q12/ADTB1; GEM:08p11/CLAPM2; GEM:00.0/CLAPG1 |
|
REF |
CLO,SEQ,MOU "Robinson MS: J Cell Biol, 108, 833-842, 1989 |
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KEY |
cysk, mem |
|
CLA |
coding, basic |
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LOC |
RS |
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MIM |
MIM: 601026 |
