Gene: [01p31/PRKAA2] protein kinase, AMP-activated, alpha 2 catalytic subunit;
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FUN |
AMP-activated protein kinase plays a key role in the regulation of fatty acid and cholesterol metabolism (Hardie-1992). In vitro, it phosphorylates and inactivates 3-hydroxy-3-methylglutaryl-CoA reductase (GEM:05q1/HMGCR) and acetyl-CoA carboxylase (GEM:17q21/ACACA), key enzymes involved in regulating de novo biosynthesis of cholesterol and fatty acids, respectively." |
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REF |
SEQ "Aguan K &: Gene, 149, 345-350, 1994 COD,SEQ,EXP,LOC "Beri RK &: FEBS Lett, 356, 117-121, 1994 FUN,EXP "Hardie DG, MacKintosh RW: BioEssays, 14, 699-704, 1992a FUN,EXP "Hardie DG: BBA, 112, 231-238, 1992b |
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KEY |
lip, ats, pep |
|
CLA |
coding, basic |
|
LOC |
01 p31 |
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MIM |
MIM: 600497 |
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EZN |
ENZYME: 2.7.1.? |
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