Gene: [05q1/HMGCR] 3-hydroxy-3-methylglutaryl-Coenzyme A reductase;
GEN | About HMGCR gene structure features, see in GEM:05p1/HMGCS1. |
FUN | [1] The enzyme
participates in mevalonic acid metabolism and biosynthesis of cholesterol
and ubiquinone progenitors. [2] Systematic name: (S)-mevalonate:NAD+ oxidoreductase (CoA-acylating). The reaction catalyzed: (S)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH." |
FAG | See GEM:05p1/HMGCS1. |
REF | EXP,MEB "Auwerx &:
PNAS, 86, N4, 1133-1137, 1989 LOC,PRO "Henry I &: CCG, 40, (HGM8), 649-650, 1985 GEN,SEQ,LOC,PRO,POL "Humphries SE &: Hum Genet, 71, 254-258, 1985 PRO,POL,MUT "Leitersdorf E &: NAR, 18, 5584, 1990 LOC,PRO "Lindgren V &: PNAS, 82, N24, 8567-8571, 1985 GEN,STR,EXP,EVO "Luskey KL &: Mol Cell Biol, 7, 1881-1893, 1987 LOC,PRO "Mohandas T &: Somat Cell Mol Genet, 12, N1, 89-94, 1986 LOC,PRO "Mohandas T &: CCG, 40, (HGM8), 700-701, 1985 |
SWI | SWISSPROT: P04035 |
KEY | lip |
CLA | coding, basic |
LOC | 05 q13.3-14 |
MIM | MIM: 142910 |
EZN | ENZYME: 1.1.1.88 |
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