Gene: [01p36/ENO1] enolase 1 (phosphopyruvate hydratase, alpha); spherocytosis, autosomal dominant;
|
GEN |
The gene length is 18 kb; exons: 12. |
|
FUN |
[1] Systematic name: 2-phospho-D-glycerate hydro-lyase.
[2] Reaction catalyzed: 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O." |
|
TIS |
Unlike the other isoforms (see GEM:12p13/ENO2 and GEM:17p1/ENO3), alpha enolase is found in many tissues." |
|
MOP |
The holoenzyme is a homodimer. MM of the alpha subunit is 44 kD. |
|
FAG |
See GEM:17p1/ENO3:FAG. |
|
PSG |
GEM:01^/ENO1P. |
|
REL |
GEM:00.0/ENO1L1. |
|
REF |
LOC,PRO "Carrit B &: Ann Hum Genet, 46, N4, 329-335, 1982 LOC,PRO "Cook PJ &: CCG, 25 (HGM5), N1-4, 9-20, 1979 MAP "D'Ancona GG &: CCG, 18, 327-332, 1977 GEN,SEQ,STR "Giallongo A &: Eur J Biochem, 190, N3, 567-573, 1990 SEQ,MOP,EXP "Giallongo A &: PNAS, 83, N18, 6741-6745, 1986 IDN,FUN,ENE,PEP "Holt A, Wold F: JBC, 236, 3227-?, 1961 MAP,EAG "Lalley PA &: PNAS, 75, 2382-2386, 1978 IDN,FUN,ENE,PEP "Westhead EW, McLain G: JBC, 239, 2464-?, 1964 |
|
KEY |
hem, glyc |
|
CLA |
coding, basic |
|
LOC |
01 pt-36.13 |
|
MIM |
MIM: 172430 |
|
EZN |
ENZYME: 4.2.1.11 |
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