Gene: [01q2/TCR2Z] T cell receptor, signal T3-zeta polypeptide (TiT3 complex); antigen CD3Z/T3, zeta polypeptide (T cell receptor); immunodeficiency combined (low expression T3-zeta chain); [CD3Z T3Z ]
|
COM |
In the GDB and HGM Catalogue, T3 element genes are designated as CD3
(according to the common name for many membrane-associated
glycoproteins of T and B cells that are markers for separate
differentiation stages: |
|
FAG |
Four different polypeptides that can form the T3 element have been identified: gamma (GEM:11q233/TCR2G), delta (GEM:11q233/TCR2D), epsilon (GEM:11q233/TCR2D), and zeta (this gene). Another protein, omega, is included in this group (mainly by convention), since it associates with the T3 element during its assembly in the endoplasmic reticulum. Three genes of this group form a cluster in chromosome 11q. The gene for zeta peptide is located in chromosome 1q. The omega peptide gene is not mapped yet (GEM:00.0/TCR2W)." |
|
EXP |
CD3H (eta) and CD3Q (theta) peptides are produced by alternative splicing of the same gene TCR2Z." |
|
MOP |
The T3 element is presumably a trimer and is noncovalently associated with a transmembrane domain of the Ti element." |
|
REL |
See FAM:TCR2/00.0. |
|
REF |
FOG,PAT "Alarcon &: New Engl J Med, 319, N18, 1203-1208, 1988 EVO,SEQ "Weissman &: Science, 239, (26 Feb), 1018-1021, 1988 FUN,MOP "Weissman &: Nature, 324, 480-482, 1986 |
|
KEY |
imm, onc, recp, hem |
|
CLA |
coding, basic |
|
LOC |
01 q22-23 |
|
MIM |
MIM: 186780 |
|
SYN |
CD3Z T3Z |
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