Gene: [03p21/GNAI2] guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; adenylate cyclase inhibitor GI, alpha-I2 (GIP2 oncogene); adrenal cortical tumor (granulosa cell tumor; thecoma); pituitary adenoma, adrenocorticotrophin hormone-secreting; [GNAI2B GIP2 ]
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GEN |
The gene length is about 16 kb. Exons: 8; introns: 7. The gene structure is identical to that of the gene coding for alpha-I3 peptide (GEM:01p13/GNAI3). Human mRNA is 2.6 kb. The 5'-flanking region is located 800 bp apart from ATG initiation codon. The promoter region contains two typical CCAAT blocks positioned 262 and 411 bp before the start, seven CCGCCC blocks, positioned 24, 62, 171, 220, 273, 382, and 455 bp before the start, as well as GC and GGGCGG (or its complement) blocks. Typical TATA-like sequences have not been found." |
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EVO |
The amino acid sequence of human alpha-I2A protein differes from that of bovine alpha-I protein by 12%. A considerable similarity occurs between the human coding region and rat GI2S (92-99%). The homology of their flanking regions is 89%." |
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EAG |
The identical murine gene is located in chr 9. |
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FAG |
For more details on GN gene family, see FAM:GNBP/00.0. |
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REF |
LOC,MOL "Blatt C &: PNAS, 85, N20, 7642-7646, 1988 FAG,SEQ "Bray P &: PNAS, 84, N15, 5115-5119, 1987 MUT,EXP,FUN "Hermouet S &: PNAS, 88, 10455-10459, 1991 SEQ,GEN,HUM,RAT,EVO "Itoh H &: JBC, 263, N14, 6656-6664, 1988 HUM,FUN,EXP,FAG "Kim SY &: PNAS, 85, N12, 4153-4157, 1988 MUT,ASS,PAT,ABR,FAG "Lyons J &: Science, 249, 655-659, 1990 PRO,LOC,FAG "Magovcevic I &: Genomics, 12, 125-129, 1992 LOC,MOL "Sparkes RS &: CCG, 46, (HGM9), 696, 1987 MUT,PAT "Williamson EA &: Eur J Clin Invest, 25, 128-131, 1995 |
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KEY |
neu, nucm, onc |
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CLA |
coding, basic |
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LOC |
03 p21.3-.2 |
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MIM |
MIM: 139360 |
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SYN |
GNAI2B GIP2 |
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