Gene: [04q1/DGI] dentinogenesis imperfecta 1; [DGI1 ]


COM

 [1] The GDB indicates the alternative location: q12-23.
[2] The HUGEN restricts the gene symbol to DGI without a figure, lest contradict the clinical classification."

HET

 In the MIM catalogue, three types of dentinogenesis imperfecta are described. Type I is considered as a syndrome of another disease, osteogenesis imperfecta (OI, type IA, MIM:166240; Levin &: Am J Med Genet, 5, 189-199, 1980; Paterson &: J Med Genet, 20, 203-205, 1983); types II and III are denoted DGI, without 'OI-IA'. Type III is described under its own number, MIM:125500, but types II and III may be allelic forms."

FAG

 Another marker related to dentin pathology has been mapped to the same region of chromosome 4 (GEM:04q1/JPD). MIM-90 does not exclude that DGI and JPD are actually related to statherin pathology (see GEM:04q1/STATH). In this arm of Chr 4, one more salivary protein gene is mapped (GEM:04q13/HTN1)."

REF

 LOC,LIN "Ball SP &: Ann Hum Genet, 46, 35-40, 1982
PHE,FOG "Bixler &: J Dent Res, 48, 1196-1199, 1969
LOC,LIN "Boughman JA &: J Craniofac Genet Dev Biol, 6, 341-350, 1986
LOC,LIN "Conneally &: CCG, 37, (HGM7), 438, 1984
LOC,LIN "Corney &: CCG, 37, (HGM7), 439, 1984
LOC,LIN "Crall &: CCG, 46, (HGM9), 600, 1987
PHE,FOG "Giansanti, Budnick: J Am Dent Assoc, 90, 439-443, 1975
PHE,FOG "Levin &: Oral Surg Oral Med Oral Path, 56, 267-274, 1983
PHE,FOG "Mars &: Brit Dent J, 140, 206-209, 1976
LOC,LIN "Roulston &: AJHG, 37, A206, 1985
PHE,FOG "Shields &: Arch Oral Biol, 18, 543-553, 1973
PHE,FOG "Shokeir MH: Clin Genet, 3, 442-447, 1972
PHE,FOG "Witkop CJ: Dent Clin N Am, 19, 25-45, 1975
PHE,FOG "Witkop CJ: Oral Surg, 32, 278-316, 1971a
PHE,FOG "Witkop CJ, Rao: Birth Def Orig Art Ser, 7, N7, 153-184, 1971b

KEY

 devd, dent

CLA

 unknown, basic

LOC

 04 q1

MIM

 MIM: 125490

SYN

 DGI1