Gene: [05p1/HMGCS1] 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble);
GEN | The characteristic feature of the HMGCS and HMGCR (3-hydroxy-3- methylglutaryl coenzyme A reductase) genes is the 5'-untranslated region complex structure containing multiple transcription initiation sites and an intron with a variable donor splice site." |
FUN | [1] The HMGCS enzyme
is involved in mevalonic acid metabolism as well as in biosynthesis of
cholesterol and ubiquinone progenitors. [2] Systematic name: 3-hydroxy-3-methylglutaryl coenzyme A acetoacetyl-CoA lyase. The catalyzed reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + CoA = = acetyl-CoA + H(2)O + acetoacetyl-CoA." |
FAG | [1] Two consecutive reactions in cholesterol
biosynthesis are catalyzed by 3-hydroxy-3-methylglutaryl coenzyme A
synthase and 3-hydroxy-3-methylglutaryl coenzyme A reductase, which are
encoded by unlinked genes located on the different arms of chr 5 (GEM:05q1/HMGCR). [2] On mitochondrial HMG-synthase see GEM:01p1/HMGCS2." |
REF | PRO,SEQ,EXP "Gil G &: PNAS, 84, N7, 1863-1866, 1987 LOC,CYG "Leonard S &: PNAS, 83, N7, 2187-2189, 1986 LOC,MOL,EVO "Mehrabian M &: JBC, 261, 16249-16255, 1986 |
SWI | SWISSPROT: Q01581 |
KEY | lip, ster, ats |
CLA | coding, basic |
LOC | 05 p14-13 |
MIM | MIM: 142940 |
EZN | ENZYME: 4.1.3.5 |
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