Gene: [11p155/ADCR] adrenocortical carcinoma; breast cancer chromosome region? (liability); [ADCC ACC BCCR ]


COM

The locus ADCR was excluded from the HGM and GDB catalogues without explaining a reason for it to be done. Probably the authors of these sources supposed that adrenocortical carcinoma and other tumors are related with a complex locus referred to as multiple tumor-associated chromosome region 1 (GEM:11p155/MTACR1)."

HET

[1] According to Henry-1987/89 (HGM9/10), tumors of many organs may be related to this locus, including breast cancer (BCCR), rhabdomyosarcoma (RMSCR; MIM:268210/RMS1), hepatoblastoma, and nephroblastoma. Therefore loci BCCR and RMSCR indicated in HGM9.5 was excluded from the following HGM and GEM catalogues.
[2] On rhabdomyosarcoma, see GEM:11p154/MYOD1.
[3] Chr 11 contains a number of the loci related with liability to tumors in various organs: GEM:11p155/CDKN1C; GEM:11p155/HRAS; GEM:11p155/MTACR1; GEM:11p154/MYOD1; GEM:11p153/LMO1; GEM:11p13/GUD; GEM:11p13/WT1; GEM:11p1/SPI1; GEM:11p1/ST2; and GEM:11q/ST3."

REF

FAG,LIN,PAT,HET "Ali &: Science, 238, 185-188, 1987
FAG,LIN,PAT,HET "Henry I &: CCG, 51, (HGM10), 1012-1013, 1989a
LOC,LIN,MOL "Henry I &: CCG, 51, (HGM10), 1013, 1989b
LOC,LIN,MOL "Henry I &: Hum Genet, 81, 273-277, 1989c
LOC,LIN,MOL "Henry I &: PNAS, 86, 3247-3251, 1989d
LOC,LIN,MOL "Henry I &: Ann Genet, 31, 216-220, 1988
LOC,LIN,MOL "Henry I &: CCG, 46, (HGM9), 629, 1987
FAG,LIN,PAT,HET "Scrable HJ &: Nature, 329, (15 Oct), 645-647, 1987

KEY

onc, horm

CLA

unknown, basic

LOC

11 p15.5

MIM

MIM: 202300

SYN

ADCC ACC BCCR

鸯铗痂蝈 蜞赕:

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  • Gene: [13^/BCS1] breast cancer, ductal, suppressor 1; [BRCD1 BCDS1 ]