Gene: [21q223/TFF1] trefoil factor 1 (PH1.A); protein pS2 (estrogen-inducible sequence; growth factor); estrogen-inducible sequence, expressed in breast cancer; [BCEI PS2 ]

EXP	BCEI transcript was identified in the tumor cell line MCF-7 after the estrogen induction, as well as in 40% of breast epitheliomas. The translation product, a small secreted protein, was found only in tumor tissue; its expression significantly correlates with the presence of progesterone and estrogen receptors."
HET	On genes determining other types of breast cancer, see GEM:01p36/BCS2, GEM:13^/BCS1, and GEM:11p155/ADCR."
POL	The gene is completely linked (teta=0) with two RFLPs: BamHI RFLP with two alleles - 8.5 kb (0.25) and 3.5 kb (0.75) - and a constant fragment 0.7 kb, and BstEII RFLP with two alleles - 3.7 kb (0.80) and 2.7 kb (0.20) - and a constant fragment 6.0 kb."
PRO	Probe pS2 is a cDNA fragment of 559 bp (including the poly(A) tail) cloned at PstI site in the plasmid pBR322."
FAG	About other P-type (treoil) domain peptides see factor 2 (GEM:21q223/TFF2) and factor 3 (GEM:21q223/TFF3) which tightly linked to factor 1 (Chinery-1996)."
REF	LOC,POL "Avramopoulos D &: Genomics, 15, 98-102, 1993 LIN,LOC "Chinery R &: Genomics, 32, N2, 281-284, 1996 LOC,POL "Chumakov I &: Nature, 359, 380-387, 1992 LOC,POL "Cohen-Haguenaer &: CCG, 40, (HGM8), 606, 1985 PRO,SEQ "Jakowlew SB &: NAR, 12, 2861-2878, 1984 GEN,SEQ "Jeltsch J-M&: NAR, 15, 1401-1414, 1987 LOC,POL "Martin V &: Gene, 157, N1-2, 261-264, 1995 PRO,EXP "Masiakowski P &: NAR, 10, 7895-7903, 1982 LOC,POL "Moisan JP &: Hum Genet, 79, 168-171, 1988 LOC,POL "Moisan JP &: CCG, 40, (HGM8), 701-702, 1985 MEB "Nunez &: Endocrinology, 121, 1759-1765, 1987 PRO,SEQ "Prud'homme JF &: DNA, 4, 11-21, 1985 PRO,SEQ "Rio MC &: PNAS, 84, 9243-9247, 1987 PRO,SEQ "Roberts M &: BBRC, 151, 306-313, 1988
SWI	SWISSPROT: P04155
KEY	onc, horm
CLA	coding, basic
LOC	21 q22.3
MIM	MIM: 113710
SYN	BCEI PS2