Gene: [11q13/IGER] IgE responsiveness (atopic); atopic hypersensitivity (allergic asthma and rhinitis, liability 2); [APY ]
|
COM |
[1] As for atopies (principally allergic asthma and rhinitis), the MIM
and GEM Catalogues mention, in addition to this marker, two others,
the genetic and functional relationships between them remaining
unclear (GEM:01q23/IGHER1A; GEM:13q14/IGHEE).
[2] MIM describes the markers APY (this locus) and IGEL (GEM:13q14/IGHEE) under the same number, although it indicates that they are determined by different genes in Chrs 11 and 13." |
|
REF |
LIN,LOC "Amelung PJ &: Clin Exp Allergy, 22, 1077-1084, 1992 LIN,LOC "Coleman R &: Lancet, 341, 1121-1122, 1993 LIN,PAT,FOG "Cookson WO &: Lancet, 340, N8816, 381-384, 1992 LOC,LIN,MOL "Cookson WO &: CCG, 51, (HGM10), 979, 1989a LIN,PAT,FOG "Cookson WO &: Lancet, 1, 1292-1295, 1989b FOG "Cookson WO, Hopkin: Lancet, 1, 86-88, 1988 LIN,LOC "Hizawa N &: J Med Genet, 32, 363-369, 1995 LIN,LOC "Hizawa N &: Clin Exp Allergy, 22, 1065-1069, 1992 LIN,LOC "Lympany P &: Clin Exp Allergy, 22, 1085-1092, 1992a LIN,LOC "Lympany P &: J Allergy Clin Immunol, 89, 619-628, 1992b LIN,LOC "Moffatt MF &: Clin Exp Allergy, 22, 1046-1051, 1992 LIN,LOC "Rich SS &: Clin Exp Allergy, 22, 1070-1076, 1992 LIN,LOC "Sandford AJ &: Lancet, 341, 332-334, 1993 LIN,LOC "Shirakawa T &: Clin Genet, 46, 228-232, 1994 LIN,LOC "Shirakawa T &: CCG, 58, 1970-1971, 1991 LIN,LOC "Young RP &: J Med Genet, 29, 236-238, 1992 LIN,LOC "Young RP &: CCG, 58, 1974-1975, 1991 |
|
KEY |
imm, mfd |
|
CLA |
unknown, basic |
|
LOC |
11 q13 |
|
MIM |
MIM: 147050 |
|
SYN |
APY |
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