Gene: [19p133/IGHER2] immunoglobulin E Fc-receptor II (low-affinity; antigen CD23); atopy 4? (allergic asthma and hay fever, liability 4); [CD23A FCE2 ]

MOP	Two receptors for IgE Fc domain are identified: the high-affinity one (receptor 1, FCE1A) and the low-affinity one (receptor 2, FCE2). Receptor 1 is supposed to be formed by three subunits; for more details, see GEM:01q23/IGHER1A. The gene for receptor 2 is cloned, and its coding region is sequenced. The soluble form of the receptor has MM 43-45 kD. This protein shares homology with animal lectins."
FAG	The gene for alpha subunit is mapped to chr 1q (GEM:01q23/IGHER1A). On other genes, see GEM:01q23/IGHER1A."
PAT	MIM and HGM mention two other markers (besides IGHER1A locus) in connection with atopies (mainly bronchial asthma and hay fever or allergic rhinitis): GEM:11q13/IGER and GEM:13q14/IGHEE. Genetic and functional relationships between these markers remain unclear. It is possible that genes for receptor 1 subunits and for receptor 2 are related with those atopies, which clinical genetic heterogeneity was demonstrated previously with formal genetic methods. Therefore, the GEM catalogue has included at least four types of atopy liability."
REF	EXP,MEB,PAT "Bujanovski-Veber &: Immunology, 66, N4, 505-511, 1989 REV,FUN,EXP,MOP "Delespesse &: Int Arch Allerg Immunol, 88, 18-22, 1989 EXP,MEB,PAT "Hivroz &: Eur J Immunol, 19, N6, 1025-1030, 1989 PRO,COD,SEQ,EVO "Ikuta K &: PNAS, 84, N3, 819-823, 1987 MEB,FUN "Kikutani H &: Cell, 47, 657-662, 1986 EXP,MEB,PAT "Nosoda &: J Immunol, 143, N1, 147-153, 1989 LOC,CYG "Wendel-Hansen V &: Somat Cell Mol Genet, 16, N3, 283-285, 1990
KEY	imm, img, recp, mfd, cyk
CLA	coding, basic
LOC	19 p13.3
MIM	MIM: 151445
SYN	CD23A FCE2