Gene: [11q223/MMP3] matrix metalloproteinase 3; stromelysin 1 (proteoglycanase; transin 1);


FUN

Stromelysin is an extracellular endopeptidase of various tissues. It belongs to collagenase-related connective tissue-degrading metalloproteinases. Stromelysin catalyses degradation of proteoglycans, fibronectin, collagen type III, IV, V and IX, and activates procollagenase."

FAG

[1] Two other collagenase genes were identified in the chromosome segment 11q2. One of the enzymes digests collagene peptides I, II, and III; its defect determines the autosomal recessive epidermolysis bullosa (GEM:11q223/MMP1). The other one - neutrophil collagenase - is described in less details (GEM:11q223/MMP8). In addition, a so called collagenase 4 is identified. It digests only collagen IV. Two collagenase 4 genes are mapped in chr 16, GEM:16q122/MMP2 and GEM:20q1/MMP9).
[2] Elements of stromelysin subfamily are cloned, and some of them are sequenced. These are stromelysins 2 (Muller-1988; GEM:11q223/MMP10) and 3 (Basset-1990; GEM:22q112/MMP11), as well as less similar to them pump-1 (putative metalloproteinase 1; Muller-1988; GEM:11q223/MMP7)."

REF

FAG,COD,SEQ "Basset P &: Nature, 348, (20/27 Dec), 699-704, 1990
LOC,LIN,MOL "Gatti &: AJHG, 45, A140, 1989
TRC,EXP "Kerr LD &: Science, 242, 1424-1427, 1988
FAG,COD,SEQ "Muller D &: Biochem J, 253, 187-192, 1988
MAP "Pendas AM &: Genomics, 37, 266-269, 1996
TRC,SEQ,EVO,EXP "Quinones S &: JBC, 264, N14, 8339-8344, 1989
CLO,COD,SEQ,PEP,EVO,EXP "Saus J &: JBC, 263, N14, 6742-6745, 1988
FUN,REV "Sellers, Murphy: Int Rev Connect Tissue Res, 9, 151-190, 1981
PRO,EXP,FAG "Sirum KL, Brinckerhoff: Biochemistry, 28, 8691-8698, 1989
LOC,MOL,POL,FAG "Spurr NK &: Genomics, 2, 119-127, 1988
CLO,COD,SEQ,EVO "Whitham SE &: Biochem J, 240, 913-916, 1986
PEP,SEQ,MOP "Wilhelm SM &: PNAS, 84, N19, 6725-6729, 1987

SWI

SWISSPROT: P08254

KEY

exce, pep

CLA

coding, basic

LOC

11 q22.3

MIM

MIM: 185250

EZN

ENZYME: 3.4.24.17

Смотрите также:

  • Инвазия опухолевая: протеазы
  • Стромелизин-1 (ММP-3)
  • MMP: эмбриогенез и морфогенез: MMP: деструкция матрикса
  • Gene: [11q223/MMP12] matrix metalloproteinase 12 (macrophage elastase);
  • Gene: [11q223/MMP13] matrix metalloproteinase 13 (zinc); collagenase 3;
  • Ген стромелизина: экспрессия