Gene: [12p1/ELA1] elastase 1 (pancreatic);


COM

[1] The GDB indicates only chromosomal but not regional localizatrion for ELA1.
[2] The MIM catalogues indicate an old code for elastase 1 (EC_3.4.4.7)."

FAG

There are three human elastase genes.
[1] ELA1 codes for a serine proteinase that is synthesized by pancreatic acinar cells. It hydrolyses many proteins, including elastin (an unsoluble connective tissue protein; GEM:07q1123/ELN);
[2] ELA2 was identified (cDNA was cloned and amino acid sequence of the protein was determined) and mapped to Chr 19 (GEM:19p133/ELA2);
[3] ELA3 (NE; GEM:11q14/ELA3) is expressed predominantly in bone marrow promyelocytes; macrophage phagolysosomes serve only as a secondary depot. Therefore its conventional name NE (neutrophil elastase) is not quite correct."

FUN

Elastase 1 but not elastase 3 activity is suppressed by alpha-1 protease inhibitor (antitrypsin; GEM:14q321/PI1)."

REF

LOC,CYG,LIN,MOL "Gerald PS, Grzeschik: CCG, 37, (HGM7), 103-126, 1984
LOC,CYG,LIN,MOL "Honey NK &: CCG, 37, (HGM7), 492, 1984a
LOC,CYG,LIN,MOL "Honey NK &: Somat Cell Mol Genet, 10, 369-376, 1984b
LOC,LIN,POL "O'Connell P &: Genomics, 1, N1, 93-102, 1987
LOC,LIN,POL "O'Connell P &: AJHG, 37, A169, 1985
GEN,EXP,SEQ,EVO "Tani T &: J Biochem, 101, N3, 591-599, 1987

SWI

SWISSPROT: P11423

KEY

pep, lys

CLA

coding, basic

LOC

12 p1

MIM

MIM: 130120

EZN

ENZYME: 3.4.21.36

鸯铗痂蝈 蜞赕:

  • 缅 囫蜞琨-I