Gene: [19p133/ELA2] elastase 2 (neutrophil?);
|
COM |
The gene NE (GEM:11q14/ELA3) is expressed predominantly in bone marrow promyelocytes; the macrophage phagolysosomes are only a secondary depot. Therefore its conventional denotation NE (Neutrophil Elastase) is not quite correct. The MIM Catalogue describes it as medullasin." |
|
FAG |
[1] There are at least three different enzymes that are called 'elastase'.
The isoform 1 (GEM:12p1/ELA1), which is
synthesized by pancreatic acinar
cells, is a serine protease hidrolysing many proteins, including elastin
(an unsoluble connective tissue protein, see GEM:07q1123/ELN).
[2] ELA2 gene is cloned as a part of cDNA and mapped to Chr 19." |
|
REF |
CLO,SEQ,EXP "Fletcher TS &: Biochemistry, 26, 7256-7261, 1987 CLO,COD,EXP "Kawashima I &: DNA, 6, 163-172, 1987 |
|
KEY |
pep, exce |
|
CLA |
coding, basic |
|
LOC |
19 p13.3 |
|
MIM |
MIM: 130130 |
|
EZN |
ENZYME: 3.4.21.37 |
