Gene: [11q14/ELA3] elastase 3, neutrophil (medullasin, bone marrow serine protease);


COM

NE is mentioned under MIM:130120 in description of ELA1.

TIS

ELA3 is expressed primarily in promyelocytes of bone marrow, while the macrophage phagolysosomes serve only for secondary storage. Therefore the conventional name neutrophil elastase (NE) is not quite correct."

FUN

Elastase 3 is a metalloproteinase; its activity is not suppressed by alpha-1 protease inhibitor (see antitrypsin, GEM:14q321/PI1), in contrast to the elastase 1 activity."

FAG

There are at least three different enzymes named 'elastase', and much controversion exists in literature on this item. Elastase 1 (GEM:12p1/ELA1) is a serine protease synthesized by the pancreatic acinar cells. It hydrolyses many proteins, including elastin (an unsoluble connective tissue protein, GEM:07q1123/ELN). Gene ELA2 was identified (cDNA cloned and the amino acid sequence of the protein determined) and mapped to chr 19 (GEM:19p133/ELA2)."

REF

CLO,SEQ,COD,EXP "Aoki Y, Hase T: BBRC, 178, 501-506, 1991
IDN,MEB,FUN "Aoki Y: JBC, 283, 2026-2032, 1978
CLO,SEQ,GEN,PEP,EXP "Nakamura H &: NAR, 15, 9601-9602, 1987
CLO,SEQ,COD,EXP "Okano K &: BBRC, 167, 1326-1332, 1990
CLO,SEQ,COD,EXP "Okano K &: J Biochem, 102, 13-16, 1987
FUN,PEP,SEQ,EVO "Sinha S &: PNAS, 84, N8, 2228-2232, 1987
GEN,SEQ,MOP,LOC "Takahashi H &: JBC, 263, N29, 14739-14747, 1988

KEY

pulm, pep

CLA

coding, basic

LOC

11 q14

MIM

MIM: 130130

EZN

ENZYME: 3.4.21.37

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