Gene: [14q112/CTLA1] cytotoxic T-lymphocyte-associated serine esterase 1 (CSP-B); granzyme B (cathepsin G-like enzyme 1); T cell/natural killer cells serine esterase 1;


MAP

Loci: GEM:14q112/CTSG; GEM:14q112/CTSGL2.
[1] CTLA1-CTSGL2-CTSG [app.50kb](Hanson-1990). Com. All the three genes belong to the tandem cluster of cathepsin G-like serine proteases."

FAG

Three genes for serine proteases expressed in T killers are mapped in the human genome: CTLA1, GEM:05q1/CTLA3, and GEM:02q33/CTLA4."

FUN

Preferential cleavage: asp-|-xaa >> asn-|-xaa > met-|-xaa, ser-|-xaa.

REL

GEM:05q1/CTLA3; GEM:02q33/CTLA4; GEM:02q31/IL17. See also GEM:14q112/CTSGL2; GEM:00.0/GZMK; GEM:19p133/GZMM."

REF

PRO,GEN,LIN,FAG,MAF "Hanson RD &: PNAS, 87, N3, 960-963, 1990
PRO,LOC,EAG,HUM,MOU "Harper K &: Immunogenetics, 28, 439-444, 1988
PRO,GEN,LOC "Klein JL &: Genomics, 5, 110-117, 1989
LOC,LIN,MOL "Lin CC &: CCG, 53, N2-3, 169-171, 1990
EXP "Schmid J, Weissman: J Immunol, 139, 250-256, 1987
PRO,COD,SEQ,EXP,EVO,HUM,MOU "Trapani JA &: PNAS, 85, N18, 6924-6928, 1988

SWI

SWISSPROT: P10144

KEY

imm, pep

CLA

coding, basic

LOC

14 q11.2

MIM

MIM: 123910

EZN

ENZYME: 3.4.21.79

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