Gene: [14q112/CTSG] cathepsin G;


FAG

[1] Cathepsin G is a component of the group of serine proteinases found inside the azurophilic granules of neitrophils and monocytes at promyelocytic and promonocytic stages of leucocyte differentiation.
[2] On other cathepsins, see GEM:08p22/CTSB.
[3] This gene is very similar, with respect to the general structure, to other serine proteinase genes - so called neutrophilic elastase (GEM:11q14/ELA3) and myeloperoxidase (GEM:17q2/MPO)."

GEN

[1] The gene length is 2.7 kb. Exons: 5 (83/147/135/253, and 256 bp), exon 1 including also 28 5'-untranslated nucleotides, beginning with the sequence aac.., where is so called TI site (transcription initiation, TIS); introns: 4 (755, 453, 170 and 433 bp).
[2] The 5'-untranscribed gene region contains the canonical promoter (TATA box) in position -29 and an additional promoter (CAAT box) in position -69; the 3'-untranslated region (87 bp, including the stop codon) contains, beginning with the 57th base pair, the canonical poly(A) signal (AATAAA motif) and, 30 bp apart, poly(A) site <..aat..>."

MAP

Loci: GEM:14q112/CTLA1; GEM:14q112/CTSGL2.
[1] See GEM:14q112/CTLA1."

REF

PRO,GEN,LOC,FAG,MAF "Hanson RD &: PNAS, 87, N3, 960-963, 1990
GEN,SEQ,EVO,FAG,LOC "Hohn PA &: JBC, 264, N23, 13412-13419, 1989
PRO,SEQ,EXP "Salvesen G &: Biochemistry, 26, 2289-2293, 1987

SWI

SWISSPROT: P08311

KEY

pep, lys

CLA

coding, basic

LOC

14 q11.2

MIM

MIM: 116830

EZN

ENZYME: 3.4.21.20

鸯铗痂蝈 蜞赕:

  • Gene: [15q2/CTSH] cathepsin H;