Gene: [14q112/CTSG] cathepsin G;
FAG | [1]
Cathepsin G is a component of the group of serine proteinases found inside
the azurophilic granules of neitrophils and monocytes at promyelocytic and
promonocytic stages of leucocyte differentiation. [2] On other cathepsins, see GEM:08p22/CTSB. [3] This gene is very similar, with respect to the general structure, to other serine proteinase genes - so called neutrophilic elastase (GEM:11q14/ELA3) and myeloperoxidase (GEM:17q2/MPO)." |
GEN | [1] The gene length is
2.7 kb. Exons: 5 (83/147/135/253, and 256 bp), exon 1 including also 28
5'-untranslated nucleotides, beginning with the sequence [2] The 5'-untranscribed gene region contains the canonical promoter (TATA box) in position -29 and an additional promoter (CAAT box) in position -69; the 3'-untranslated region (87 bp, including the stop codon) contains, beginning with the 57th base pair, the canonical poly(A) signal (AATAAA motif) and, 30 bp apart, poly(A) site <..aat..>." |
MAP | Loci: GEM:14q112/CTLA1; GEM:14q112/CTSGL2. [1] See GEM:14q112/CTLA1." |
REF | PRO,GEN,LOC,FAG,MAF
"Hanson RD &: PNAS, 87, N3, 960-963, 1990 GEN,SEQ,EVO,FAG,LOC "Hohn PA &: JBC, 264, N23, 13412-13419, 1989 PRO,SEQ,EXP "Salvesen G &: Biochemistry, 26, 2289-2293, 1987 |
SWI | SWISSPROT: P08311 |
KEY | pep, lys |
CLA | coding, basic |
LOC | 14 q11.2 |
MIM | MIM: 116830 |
EZN | ENZYME: 3.4.21.20 |
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