Gene: [19p12/PAR4] proteinase activated (protease-activated) receptor 4;


COM

The PAR4 gene was mapped to 19p12 by FISH (Xu-1998).

FUN

Studies with PAR-activating peptides suggest that PAR4 functions in human platelets, which implies that an analogous dual-receptor system operates in humans as well as in mice. The identification of a 2-receptor system for platelet activation by thrombin has important implications for the development of antithrombotic therapies (Xu-1998)."

REF

FUN,EXP "Kahn ML &: Nature, 394, 690-694, 1998
COD,SEQ,LOC "Xu W-F &: PNAS, 95, 6642-6646, 1998

KEY

hem, clot, recp

CLA

coding, basic

LOC

19 p12

MIM

MIM: 602779

鸯铗痂蝈 蜞赕:

  • Gene: [05q13/F2R] coagulation factor II (thrombin) receptor; proteinase activated (protease-activated) receptor 1; [TR CF2R PAR1 ]
  • PAR4 疱鲥矧铕 蝠铎徼磬