Gene: [20^/ADRA1A] adrenergic, alpha-1A-, receptor; [ADRA1R ]


FAG

The following genes coding for alpha-adrenergic receptor peptides are identified: GEM:05q33/ADRA1B; GEM:08p21/ADRA1C; GEM:10q25/ADRA2A; GEM:02^/ADRA2B; GEM:04p1/ADRA2C."

HET

Alpha-adrenergic receptor peptides possess heterogeneity in several features such as chlorethylclonidine antagonist sensitivity: high-affinity alpha-1A receptors are not sensitive to WB4101 and low-affinity alpha-1B receptors are irreversibly blocked with chlorethylclonidine."

REL

GEM:10q25/ADRB1; GEM:05q3/ADRB2; GEM:08p1/ADRB3; GEM:11q13/ADRBK1; GEM:22q11/ADRBK2"

REF

ROD,EVO,PRO,EXP "Cotecchia &: PNAS, 85, N19, 7159-7163, 1988
REV,FAG "Lefkowitz, Caron: JBC, 263, N11, 4993-4996, 1988
LOC "Loftus SK &: CCG, 67, N2, 69-74, 1994
FUN,HET,PAT "Mignot &: Brain Res, 490, 186-191, 1989
EVO,FAG "Regan JW &: PNAS, 85, N17, 6301-6305, 1988
EVO,FAG "Shreeve &: PNAS, 82, (Jul), 4842-4846, 1985
LOC,FAG,EAG "Yang-Feng TL &: PNAS, 87, N4, 1516-1520, 1990
FAG "Yang-Feng TL &: CCG, 46, (HGM9), 722-723, 1987

SWI

SWISSPROT: P25100

KEY

neu, recp, mem, sign

CLA

coding, basic

LOC

20?

MIM

MIM: 104219

SYN

ADRA1R

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