Gene: [22q1/PDGFB] platelet-derived growth factor, beta polypeptide; simian sarcoma viral oncogene homolog; [PDGF2 SIS
]
|
GEN |
[1] The gene length is 24.3 kb. Exons: 6 (723 bp in total); introns: 5
(8.8, 2, 1.5, 1.5, 6.8, and 0.3 kb; 20.9 kb in total); 5'-unt = 1022 bp; 3'-unt = 1625 bp. [2] The mature mRNA is 3.4 kb; the precursor protein comprises 241 amino acid residues." |
|
MOP |
The active PDGF protein is considered to be a heterodimer consisting of related but not identical peptides A and B (recently homodimer isoforms, AA and BB, were also isolated)." |
|
FAG |
A high-affinity receptor has been identified, which is apparently specific for the BB isoform; its gene is mapped to chr 5q (GEM:05q3/PDGFRB)." |
|
REF |
LOC,CYG,MOL "Bartram CR &: Blood, 63, N1, 223-225, 1984 CLO,SEQ,EXP,MOP,EVO "Collins T &: Nature, 316, 748-750, 1985 LOC,CYG,MOL "Dalla-Favera R &: Science, 218, 686-688, 1982 GEN,PRO,MOP,FUN "Dalla-Favera R &: Nature, 292, 31-35, 1981 IDN,EXP,MOP "Deuel &: Science, 221, 1348-1350, 1983 GEN,PRO,MOP,FUN "Devare SG &: PNAS, 80, 731-735, 1983 CLO,SEQ,EXP,MOP,EVO "Doolittle &: Science, 221, (15 Jul), 275-277, 1983 LOC,CYG,MOL "Goyns MH: Biosci Rep, 3, 1107-1111, 1983 LOC,CYG,MOL "Groffen J &: J Exp Med, 158, 9-15, 1983 LOC,LIN,MOL,POL "Heines &: CCG, 46, (HGM9), 625, 1987 REV "Heldin, Westermark: Brit Med Bull, 45, N2, 453-464, 1989 LOC,CYG,MOL "Jhanwar SC &: CCG, 38, 73-75, 1984 CLO,SEQ,EXP,MOP,EVO "Josephs SF &: Science, 223, 487-491, 1984a CLO,SEQ,EXP,MOP,EVO "Josephs SF &: Science, 225, (10 Aug), 636-639, 1984b CLO,SEQ,EXP,MOP,EVO "Josephs SF &: Science, 219, 503-505, 1983 LOC,LIN,MOL,POL "Julier C &: AJHG, 42, 297-308, 1988 LOC,LIN,MOL,POL "Julier C &: CCG, 40, (HGM8), 663, 1985a LOC,LIN,MOL,POL "Julier C &: CCG, 40, (HGM8), 664, 1985b LOC,LIN,MOL,POL "Julier C &: CCG, 40, (HGM8), 665, 1985c IDN,EXP,MOP "Kelly &: EMBO J, 4, 3399-3405, 1985 IDN,EXP,MOP "Leal &: Science, 230, 327-330, 1985 IDN,EXP,MOP "Owen &: Science, 225, 54-56, 1984 GEN,PRO,MOP,FUN "Rao CD &: Cold Spring Harbor Symp, 51, (Part 2), 959-966, 1986a CLO,SEQ,EXP,MOP,EVO "Rao CD &: PNAS, 83, N8, 2392-2396, 1986b CLO,SEQ,EXP,MOP,EVO "Ratner L &: NAR, 13, N14, 5007-5018, 1985 IDN,EXP,MOP "Robbins &: Nature, 305, (13 Oct), 605-608, 1983 IDN,EXP,MOP "Robbins &: Science, 218, 1131-1133, 1982 REV "Ross R: Lancet, 1, (27 May), 1179-1182, 1989 LOC,CYG,MOL "Swan DC &: PNAS, 79, 4691-4695, 1982 IDN,EXP,MOP "Waterfield MD &: Nature, 304, 35-39, 1983 REV "Westermark, Heldin: J Int Med, 225, 55-58, 1989 |
|
KEY |
onc, cyk, hem |
|
CLA |
coding, basic |
|
LOC |
22 q12.3-13.1 |
|
MIM |
MIM: 190040 |
|
SYN |
PDGF2 SIS |
Смотрите также:
